Cross-correlation analysis of pulse wave propagation in arteries: in vitro validation and in vivo feasibility.
Cross-correlation analysis of pulse wave propagation in arteries: in vitro validation and in vivo feasibility.
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DOI：
10.1088/1361-6560/aabe57
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发表时间：
2018-05-29
影响因子：
3.5
通讯作者：
Konofagou E
中科院分区：
文献类型：
--
作者：
Nauleau P;Apostolakis I;McGarry M;Konofagou E
众所周知，动脉僵硬度是各种心血管疾病进展的指标。临床上，脉搏波速度（PWV）用作动脉僵硬度的替代指标。脉搏波成像 (PWI) 是一种基于超声的非侵入性成像技术，能够绘制血管壁的运动图，从而对动脉特性进行局部评估。传统上，通过在地图上跟踪位移波的显着特征（例如 50% 上冲程）来估计 PWV。然而，反射的存在，例如在颈动脉分叉处产生的反射，可能会使 PWV 估计产生偏差。在本文中，我们提出了一种基于两步互相关的方法，利用 PWI 时空图中的可用信息来表征动脉。首先，提出互相关曲线下的面积作为定位不同属性区域的指标。其次，跟踪互相关函数的局部峰值以获得偏差较小的 PWV 估计。在模型中进行了三个系列的实验，以评估所提出的方法的能力并将其与传统方法进行比较。在均匀体模的理想情况下，两种方法表现相似并正确估计 PWV。在存在反射的情况下，所提出的方法提供了比传统处理更准确的估计：例如，对于软体模，观察到-0.27和-0.71 m·s−1的偏差。在第三系列实验中，基于相关性的方法能够以小于1毫米的误差定位两个不同属性的区域。它还提供了比传统处理更准确的 PWV 估计（偏差：-0.12 与 -0.26 m·s−1）。最后，在十一名健康受试者中证明了所提出方法的体内可行性。结果表明，基于相关性的方法在体内的精确度可能较低，但比传统方法更准确。
The stiffness of the arteries is known to be an indicator of the progression of various cardiovascular diseases. Clinically, the pulse wave velocity (PWV) is used as a surrogate for the arterial stiffness. Pulse Wave Imaging (PWI) is a non-invasive, ultrasound-based imaging technique capable of mapping the motion of the vessel walls allowing local assessment of the arterial properties. Conventionally, a distinctive feature of the displacement wave (e.g. the 50% upstroke) is tracked across the map to estimate the PWV. However, the presence of reflections, such as those generated at the carotid bifurcation, can bias the PWV estimation. In this paper, we propose a two-step cross-correlation based methods to characterize arteries using the information available in the PWI spatio-temporal map. First, the area under the cross-correlation curve is proposed as an index to locate regions of different properties. Second, a local peak of the cross-correlation function is tracked to obtain a less biased estimate of PWV. Three series of experiments were conducted in phantoms to evaluate the capabilities of the proposed method and compare it against the conventional method. In the ideal case of a homogeneous phantom, the two methods performed similarly and estimated correctly the PWV. In the presence of reflections, the proposed method provided a more accurate estimate than the conventional processing: e.g for the soft phantom, biases of −0.27 and −0.71 m · s−1 were observed. In a third series of experiments, the correlation-based method was able to locate, with an error smaller than 1 mm, two regions of different properties. It also provided more accurate PWV estimates than the conventional processing (biases: −0.12 vs −0.26 m · s−1). Finally, in vivo feasibility of the proposed method was demonstrated in eleven healthy subjects. The results indicated that the correlation-based method might be less precise in vivo but more accurate than the conventional method.
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影响因子：
2.9
作者：
Behler, Russell H.;Nichols, Timothy C.;Gallippi, Caterina M.
通讯作者：
Gallippi, Caterina M.
DOI：
10.1098/rspb.1922.0022
发表时间：
1922-04-01
期刊：
PROCEEDINGS OF THE ROYAL SOCIETY OF LONDON SERIES B-CONTAINING PAPERS OF A BIOLOGICAL CHARACTER
影响因子：
--
作者：
Bramwell, JC
通讯作者：
Bramwell, JC
影响因子：
2.3
作者：
Meinders, JM;Kornet, L;Hoeks, APG
通讯作者：
Hoeks, APG
影响因子：
2.9
作者：
RENEMAN, RS;VANMERODE, T;HOEKS, APG
通讯作者：
HOEKS, APG
DOI：
10.1109/tuffc.2014.6689779
发表时间：
2014-01-01
影响因子：
3.6
作者：
Tanter, Mickael;Fink, Mathias
通讯作者：
Fink, Mathias