Prevalence of anxiety disorders and anxiety subtypes in patients with Parkinson's disease.
Prevalence of anxiety disorders and anxiety subtypes in patients with Parkinson's disease.
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DOI：
10.1002/mds.22611
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发表时间：
2009-07-15
影响因子：
8.6
通讯作者：
Marsh, Laura
中科院分区：
文献类型：
--
作者：
Pontone, Gregory M.;Williams, James R.;Anderson, Karen E.;Chase, Gary;Goldstein, Susanne A.;Grill, Stephen;Hirsch, Elaina S.;Lehmann, Susan;Little, John T.;Margolis, Russell L.;Rabins, Peter V.;Weiss, Howard D.;Marsh, Laura
焦虑障碍在帕金森病（PD）中很常见，但没有很好的特征。本研究确定了127名特发性PD患者样本中所有DSM-IV-TR焦虑症诊断的患病率和临床相关性，这些患者接受了精神科医生和神经科医生的综合评估。由六名具有老年精神病学和/或运动障碍专业知识的精神科医生组成的小组，通过一致同意建立所有精神病学诊断。目前和终生至少有一种焦虑症诊断的患病率分别为43% （n=55）和49% （n=63）。未特别说明的焦虑障碍是最常见的诊断（30%终生患病率，n=38）， DSM诊断用于不符合定义亚型标准的焦虑障碍。与非焦虑受试者相比，惊恐障碍（n=13）与PD发病年龄较早相关[50.3（12.2）比61.0（13.7）岁，p< 0.01]，运动波动率较高[77%（10/13）比39% (25/64),p= 0.01]和晨肌张力障碍[38%（5/13）比13% (8/62),p< 0.01]。焦虑障碍的高患病率，包括通常不符合常规诊断标准的障碍，表明PD患者的焦虑可能未被充分诊断和治疗，需要对PD患者的焦虑障碍进行精确的表征。此外，某些焦虑亚型可能是与PD疾病影响相关的临床有用标志物。
Anxiety disorders are common in Parkinson's Disease (PD), but are not well-characterized. This study determined the prevalence and clinical correlates of all DSM-IV-TR anxiety disorder diagnoses in a sample of 127 subjects with idiopathic PD who underwent comprehensive assessments administered by a psychiatrist and neurologist. A panel of six psychiatrists with expertise in geriatric psychiatry and/or movement disorders established by consensus all psychiatric diagnoses. Current and lifetime prevalence of at least one anxiety disorder diagnosis was 43% (n=55) and 49% (n=63), respectively. Anxiety Disorder Not Otherwise Specified, a DSM diagnosis used for anxiety disturbances not meeting criteria for defined subtypes, was the most common diagnosis (30% lifetime prevalence, n=38). Compared to non-anxious subjects, panic disorder (n=13) was associated with earlier age of PD onset [50.3(12.2) vs. 61.0(13.7) years, p<.01], higher rates of motor fluctuations [77% (10/13) vs. 39% (25/64), p=.01] and morning dystonia [38% (5/13) vs. 13% (8/62), p<.03]. This high prevalence of anxiety disorders, including disturbances often not meeting conventional diagnostic criteria, suggests that anxiety in PD is likely under-diagnosed and under-treated and refined characterization of anxiety disorders in PD is needed. In addition, certain anxiety subtypes may be clinically useful markers associated with disease impact in PD.
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影响因子：
11
作者：
HUGHES, AJ;DANIEL, SE;LEES, AJ
通讯作者：
LEES, AJ
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通讯作者：
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影响因子：
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作者：
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通讯作者：
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