Estrogen oversees the maintenance of the female genetic program in terminally differentiated gonochorists.
Estrogen oversees the maintenance of the female genetic program in terminally differentiated gonochorists.
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DOI：
10.1038/srep02862
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发表时间：
2013-10-07
影响因子：
4.6
通讯作者：
Nagahama, Y.
中科院分区：
文献类型：
--
作者：
Paul-Prasanth, B.;Bhandari, R. K.;Kobayashi, T.;Horiguchi, R.;Kobayashi, Y.;Nakamoto, M.;Shibata, Y.;Sakai, F.;Nakamura, M.;Nagahama, Y.
在脊椎动物中，性腺的性可塑性在性别分化完成后并不保留，除了一些雌雄同体的物种。在这里，我们报道了芳香化酶抑制剂（AI）消耗雌二醇-17β (E2)长达6个月，导致两种性成熟鱼类尼罗罗非鱼和medaka的雌性到雄性的功能性逆转。性别反转的鱼表现出典型的雄性模式，E2和雄激素水平、第二性征和雄性样性行为，产生可育精子。相反，E2联合治疗可抑制ai诱导的性别逆转。人工授精诱导的性腺原位杂交表明，成年卵巢背侧的囊肿是新形成的睾丸组织中生殖细胞和支持细胞的来源。Gonochoristic fish保持其性可塑性直到成年，E2在维持雌性表型中起着关键作用。
The sexual plasticity of the gonads is not retained after the completion of sex differentiation in vertebrates, except in some hermaphroditic species. Here, we report that the depletion of estradiol-17β (E2) by aromatase inhibitors (AI) for up to six months resulted in a functional female-to-male sex reversal in sexually-mature adults of two gonochoristic fish species, Nile tilapia and medaka. The sex-reversed fish showed a typical male pattern of E2 and androgen levels, secondary sexual characteristics, and male-like sex behavior, producing fertile sperm. Conversely, co-treatment of E2 inhibited AI-induced sex reversal. In situ hybridization of medaka gonads during AI-induced sex reversal indicated that cysts on the dorsal side of the adult ovaries are the origin of germ cells and Sertoli cells in the newly formed testicular tissue. Gonochoristic fish maintain their sexual plasticity until adulthood and E2 plays a critical role in maintaining the female phenotype.
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影响因子：
64.8
作者：
Matson, Clinton K.;Murphy, Mark W.;Sarver, Aaron L.;Griswold, Michael D.;Bardwell, Vivian J.;Zarkower, David
通讯作者：
Zarkower, David
DOI：
10.1073/pnas.1218468110
发表时间：
2013-01-29
影响因子：
11.1
作者：
Lee, Seungki;Iwasaki, Yoshiko;Yoshizaki, Goro
通讯作者：
Yoshizaki, Goro
影响因子：
64.8
作者：
Johnson, J;Canning, J;Tilly, JL
通讯作者：
Tilly, JL
影响因子：
2.5
作者：
Kwon, JY;McAndrew, BJ;Penman, DJ
通讯作者：
Penman, DJ
影响因子：
0.9
作者：
Kawahara, T;Yamashita, I
通讯作者：
Yamashita, I