Potential of targeting TGF-β for organ transplant patients.

Potential of targeting TGF-β for organ transplant patients.
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针对器官移植患者靶向TGF-β的潜力。

DOI:
10.4155/fmc.12.215
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发表时间:
2013-03
影响因子:
4.2
通讯作者:
Love R
Love R
中科院分区:
医学3区
文献类型:
--
作者:
Iwashima M;Love R

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TGF-β was originally considered as an immunoregulatory cytokine, but accumulating data demonstrate that it also plays a critical role in development of effector immunity. Since TGF-β has a potent ability to alter immune responses, modulation of the TGF-β pathway for treatment of transplantation patients could be effective if carried out in a target selective manner. This review will focus on the role of TGF-β in T cell differentiation and discuss the prospect of TGF-β as the therapeutic target of lung transplantation acceptance.
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