Histamine: neural circuits and new medications.
Histamine: neural circuits and new medications.
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DOI：
10.1093/sleep/zsy183
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发表时间：
2019-01-01
期刊：
影响因子：
5.6
通讯作者：
Dauvilliers Y
中科院分区：
文献类型：
--
作者：
Scammell TE;Jackson AC;Franks NP;Wisden W;Dauvilliers Y
大约50年前，组胺首次在大脑中被发现，但直到最近几年，研究人员才了解它如何调节睡眠/觉醒行为。我们提供了组胺系统的翻译概述，从基础研究到新的临床试验，证明了增强组胺信号的药物的有用性。结节乳头核是大脑中组胺的唯一神经元来源，并且像许多唤醒系统一样，组胺神经元弥漫性地支配皮质、丘脑和其他促进唤醒的大脑区域。组胺通常对靶神经元具有兴奋作用，但矛盾的是，组胺神经元也可以释放抑制性神经递质GABA。新的研究表明，组胺神经元的活动对于正常的觉醒至关重要，特别是在特定的昼夜节律阶段，减少这些神经元的活动可以产生镇静作用。发作性睡病中组胺神经元的数量增加，但这是否会影响大脑中组胺的水平仍有争议。具有临床重要性的是，新的化合物正在变得可用，增强组胺信号，临床试验表明，这些药物减少嗜睡症的嗜睡和昏厥。
Histamine was first identified in the brain about 50 years ago, but only in the last few years have researchers gained an understanding of how it regulates sleep/wake behavior. We provide a translational overview of the histamine system, from basic research to new clinical trials demonstrating the usefulness of drugs that enhance histamine signaling. The tuberomammillary nucleus is the sole neuronal source of histamine in the brain, and like many of the arousal systems, histamine neurons diffusely innervate the cortex, thalamus, and other wake-promoting brain regions. Histamine has generally excitatory effects on target neurons, but paradoxically, histamine neurons may also release the inhibitory neurotransmitter GABA. New research demonstrates that activity in histamine neurons is essential for normal wakefulness, especially at specific circadian phases, and reducing activity in these neurons can produce sedation. The number of histamine neurons is increased in narcolepsy, but whether this affects brain levels of histamine is controversial. Of clinical importance, new compounds are becoming available that enhance histamine signaling, and clinical trials show that these medications reduce sleepiness and cataplexy in narcolepsy.
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影响因子：
3.1
作者：
Flik, Gunnar;Folgering, Joost H. A.;Dremencov, Eliyahu
通讯作者：
Dremencov, Eliyahu
影响因子：
64.8
作者：
通讯作者：
--
影响因子：
3.4
作者：
Chen A;Singh C;Oikonomou G;Prober DA
通讯作者：
Prober DA
DOI：
10.1523/jneurosci.0460-12.2012
发表时间：
2012-08-08
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Duguid I;Branco T;London M;Chadderton P;Häusser M
通讯作者：
Häusser M
影响因子：
5.6
作者：
Dauvilliers, Yves;Delallee, Nathalie;Robert, Philippe
通讯作者：
Robert, Philippe