Major affective disorders and schizophrenia: a common molecular signature?
Major affective disorders and schizophrenia: a common molecular signature?
复制标题
主要情感障碍和精神分裂症：共同的分子特征？
作者：
A. Bogaert;J. Del;C. Broeckhoven
精神疾病，包括情感性障碍（AD）和精神分裂症（SZ）是西方人群中最常见的致残性脑部疾病，其发病率和死亡率都很高。虽然其病因和病理生理在很大程度上是未知的，但家庭、双胞胎和收养研究表明，这些疾病有很强的遗传决定作用。这些研究表明，这些疾病的遗传率在40%到85%之间，但也指出了环境因素的重要性。因此，任何旨在鉴定参与AD和SZ发展的基因的研究策略都应考虑到这些疾病的复杂性（多因素）。在过去的十年中，分子遗传学研究为识别复杂疾病中涉及的遗传因素做出了巨大贡献。在此，我们对AD和SZ最有希望的基因及其鉴定方法和途径进行了全面的综述。此外，我们还讨论了目前的知识和假设，这些假设是关于变异对蛋白质功能的影响，以及最近的观察结果，指出了共同的分子机制。植物学报，27(9),833-853,2006。©2006 Wiley‐Liss, Inc。
Psychiatric disorders, including affective disorders (AD) and schizophrenia (SZ) are among the most common disabling brain diseases in Western populations and result in high costs in terms of morbidity as well as mortality. Although their etiology and pathophysiology is largely unknown, family‐, twin‐, and adoption studies argue for a strong genetic determination of these disorders. These studies indicate that there is between 40 and 85% heritability for these disorders but point also to the importance of environmental factors. Therefore, any research strategy aiming at the identification of genes involved in the development of AD and SZ should account for the complex nature (multifactorial) of these disorders. During the last decade, molecular genetic studies have contributed a great deal to the identification of genetic factors involved in complex disorders. Here we provide a comprehensive review of the most promising genes for AD and SZ, and the methods and approaches that were used for their identification. Also, we discuss the current knowledge and hypotheses that have been formulated regarding the effect of variations on protein functioning as well as recent observations that point to common molecular mechanisms. Hum Mutat 27(9), 833–853, 2006. © 2006 Wiley‐Liss, Inc.
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DOI：
10.1017/s1461145704004663
发表时间：
2004-12-01
影响因子：
4.8
作者：
Huang, YY;Battistuzzi, C;Mann, JJ
通讯作者：
Mann, JJ
影响因子：
17.7
作者：
Malhotra, AK;Kestler, LJ;Goldman, D
通讯作者：
Goldman, D
自杀倾向的血小板标志物。
影响因子：
5.2
作者：
Meltzer,HY;Arora,RC
通讯作者：
Arora,RC
DOI：
10.1097/00004583-200012000-00018
发表时间：
2000-12-01
影响因子：
13.3
作者：
Geller, B;Bolhofner, K;Gundersen, K
通讯作者：
Gundersen, K
DOI：
10.1097/00008571-199606000-00007
发表时间：
1996-06-01
期刊：
PHARMACOGENETICS
影响因子：
--
作者：
Lachman, HM;Papolos, DF;Weinshilboum, RM
通讯作者：
Weinshilboum, RM