Methods to assess bioavailability of hydrophobic organic contaminants: Principles, operations, and limitations.
Methods to assess bioavailability of hydrophobic organic contaminants: Principles, operations, and limitations.
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DOI：
10.1016/j.envpol.2012.09.013
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发表时间：
2013-01
影响因子：
8.9
通讯作者：
Gan, Jay
中科院分区：
文献类型：
--
作者：
Cui, Xinyi;Mayer, Philipp;Gan, Jay
许多重要的环境污染物是疏水性有机污染物，其中包括多氯联苯、多环芳烃、多溴二苯醚、滴滴涕和其他氯化杀虫剂等。由于其强疏水性，HOCs的最终目的地是土壤或沉积物，其生态毒理学效应受到吸附作用的密切调节，从而影响生物利用度。过去二十年来，开发和应用基于分配的方法和仿生提取来测量HOC生物利用度的研究工作急剧增加。然而，分析方法和相关测量终点的许多变化往往是用户混淆的根源。在这篇综述中，我们根据测量目标区分了最常用的分析方法，并使用简单的流程图说明了它们的实际操作步骤、优势和局限性。这篇综述可作为新用户选择和使用已建立方法的指导，并为有经验的研究人员确定进一步研究的潜在主题提供参考。
Many important environmental contaminants are hydrophobic organic contaminants (HOCs), which include PCBs, PAHs, PBDEs, DDT and other chlorinated insecticides, among others. Owing to their strong hydrophobicity, HOCs have their final destination in soil or sediment, where their ecotoxicological effects are closely regulated by sorption and thus bioavailability. The last two decades has seen a dramatic increase in research efforts in developing and applying partitioning based methods and biomimetic extractions for measuring HOC bioavailability. However, the many variations of both analytical methods and associated measurement endpoints are often a source of confusion for users. In this review, we distinguish the most commonly used analytical approaches based on their measurement objectives, and illustrate their practical operational steps, strengths and limitations using simple flowcharts. This review may serve as guidance for new users on the selection and use of established methods, and a reference for experienced investigators to identify potential topics for further research.
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影响因子：
11.4
作者：
Chung, NH;Alexander, M
通讯作者：
Alexander, M
影响因子：
8.8
作者：
Cuypers, C;Pancras, T;Rulkens, W
通讯作者：
Rulkens, W
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11.4
作者：
Bosma, TNP;Middeldorp, PJM;Zehnder, AJB
通讯作者：
Zehnder, AJB
影响因子：
4.1
作者：
Cornelissen, Gerard;Pettersen, Arne;Breedveld, Gijs D.
通讯作者：
Breedveld, Gijs D.
影响因子：
4.3
作者：
Barthe, Mickael;Pelletier, Emilien
通讯作者：
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