The roles of COMT val158met status and aviation expertise in flight simulator performance and cognitive ability.
The roles of COMT val158met status and aviation expertise in flight simulator performance and cognitive ability.
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DOI：
10.1007/s10519-010-9436-z
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发表时间：
2011-09
影响因子：
2.6
通讯作者：
Yesavage, J. A.
中科院分区：
文献类型：
--
作者：
Kennedy, Q.;Taylor, J. L.;Noda, A.;Adamson, M.;Murphy, G. M., Jr.;Zeitzer, J. M.;Yesavage, J. A.
儿茶酚-O-甲基转移酶(COMT)基因val158met位置的多态变异与执行能力、处理速度和注意力的差异有关。这项研究的目的是：(1)复制先前COMT val158met关于认知性能的研究结果；(2)确定COMT val158met的影响是否扩展到真实世界的任务，即飞行模拟器中的飞机导航性能；以及(3)确定航空专业知识是否缓和了COMT val158met状态对飞行模拟器性能的任何影响。172名年龄在41-69岁之间的飞行员完成了飞行模拟器、认知和遗传评估，他们的航空培训水平和经验各不相同。结果表明，尽管没有发现COMT对飞行表现的总体衡量，但MET等位基因对认知能力的两个方面：执行功能和工作记忆表现都有积极的影响。与其他参与者相比，具有MET/MET基因的飞行员在交通避免措施方面受益更多，这是飞行模拟器性能的一个组成部分。这些初步结果表明，COMT val158met的多态变异可以影响现实世界的任务。
The polymorphic variation in the val158met position of the catechol-O-methyltransferase (COMT) gene is associated with differences in executive performance, processing speed, and attention. The purpose of this study is: (1) replicate previous COMT val158met findings on cognitive performance; (2) determine whether COMT val158met effects extend to a real-world task, aircraft navigation performance in a flight simulator; and (3) determine if aviation expertise moderates any effect of COMT val158met status on flight simulator performance. One hundred seventy two pilots aged 41–69 years, who varied in level of aviation training and experience, completed flight simulator, cognitive, and genetic assessments. Results indicate that although no COMT effect was found for an overall measure of flight performance, a positive effect of the met allele was detected for two aspects of cognitive ability: executive functioning and working memory performance. Pilots with the met/met genotype benefited more from increased levels of expertise than other participants on a traffic avoidance measure, which is a component of flight simulator performance. These preliminary results indicate that COMT val158met polymorphic variation can affect a real-world task.
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DOI：
10.1073/pnas.111134598
发表时间：
2001-06-05
影响因子：
11.1
作者：
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通讯作者：
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影响因子：
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影响因子：
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作者：
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影响因子：
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作者：
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通讯作者：
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