Signaling Interaction between Facial and Meningeal Inputs of the Trigeminal System Mediates Peripheral Neurostimulation Analgesia in a Rat Model of Migraine
Signaling Interaction between Facial and Meningeal Inputs of the Trigeminal System Mediates Peripheral Neurostimulation Analgesia in a Rat Model of Migraine
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三叉神经系统面部和脑膜输入之间的信号相互作用介导偏头痛大鼠模型的周围神经刺激镇痛
DOI：
10.1016/j.neuroscience.2020.03.004
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发表时间：
2020-03
期刊：
影响因子：
3.3
通讯作者：
Zhu Bing
中科院分区：
文献类型：
--
作者：
Wang Shuya;Wang Jia;Liu Kun;Bai Wanzhu;Cui Xiang;Han Shu;Gao Xinyan;Zhu Bing
在偏头痛发作期间，三叉神经区域内的周围神经刺激已被用于缓解疼痛，但这种非侵入性干预的机制基础仍然知之甚少。在这项研究中，我们通过评估硝酸甘油（NTG）诱导的大鼠偏头痛模型的镇痛作用，研究了外周刺激三叉神经的治疗作用，三叉神经为颅内结构提供同节段神经支配。由于三叉神经系统的神经源性炎症反应，通过对硬脑膜施加有害刺激可诱导面部皮肤的血浆蛋白外渗。有害化学物质刺激硬脑膜导致面部皮肤组织蛋白外渗，引起机械敏感性。通过逆行示踪双标记三叉神经节（TG）神经元，检测分叉轴突。脊髓三叉尾核（Sp5C）宽动态范围（WDR）神经元的细胞外记录显示了面部组织和硬脑膜输入的趋同和相互作用。同种异体面部组织外周神经刺激对偏头痛模型中头侧皮肤异常性疼痛有节段性疼痛抑制作用。结果表明，面部区域和颅内结构通过TG的双标记分岔神经元和二阶WDR神经元直接相连。c -纤维强度阈值的同位刺激对镇痛的抑制作用比相同强度的异位刺激强得多。这些结果为神经基础提供了新的证据，通过周围神经刺激可能有效治疗偏头痛的临床实践。
Peripheral neurostimulation within the trigeminal nerve territory has been used for pain alleviation during migraine attacks, but the mechanistic basis of this non-invasive intervention is still poorly understood. In this study, we investigated the therapeutic role of peripheral stimulation of the trigeminal nerve, which provides homosegmental innervation to intracranial structures, by assessing analgesic effects in a nitroglycerin (NTG)-induced rat model of migraine. As a result of neurogenic inflammatory responses in the trigeminal nervous system, plasma protein extravasation was induced in facial skin by applying noxious stimulation to the dura mater. Noxious chemical stimulation of the dura mater led to protein extravasation in facial cutaneous tissues and caused mechanical sensitivity. Trigeminal ganglion (TG) neurons were double-labeled via retrograde tracing to detect bifurcated axons. Extracellular recordings of wide dynamic range (WDR) neurons in the spinal trigeminal nucleus caudalis (Sp5C) demonstrated the convergence and interaction of inputs from facial tissues and the dura mater. Peripheral neurostimulation of homotopic facial tissues represented segmental pain inhibition on cephalic cutaneous allodynia in the migraine model. The results indicated that facial territories and intracranial structures were directly connected with each other through bifurcated double-labeled neurons in the TG and through second-order WDR neurons. Homotopic stimulation at the C-fiber intensity threshold resulted in much stronger inhibition of analgesia than the same intensity of heterotopic stimulation. These results provide novel evidence for the neurological bases through which peripheral neurostimulation may be effective in treating migraine in clinical practice.
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影响因子：
--
作者：
D. M. McDonald;Jeffrey J. Bowden;P. Baluk;N. Bunnett
通讯作者：
D. M. McDonald;Jeffrey J. Bowden;P. Baluk;N. Bunnett
影响因子：
4.9
作者：
C-P Yang;M.-H. Chang;Peng Liu;T-C Li;C. Hsieh;K. Hwang;H. Chang
通讯作者：
C-P Yang;M.-H. Chang;Peng Liu;T-C Li;C. Hsieh;K. Hwang;H. Chang
DOI：
10.1007/978-3-030-75239-2_2
发表时间：
2021
期刊：
Migraine
影响因子：
--
作者：
B. Mueller;N. Diaz;Jihan Grant
通讯作者：
B. Mueller;N. Diaz;Jihan Grant
DOI：
10.3791/51212
发表时间：
2013-12-19
期刊：
Journal of visualized experiments : JoVE
影响因子：
--
作者：
Martinov T;Mack M;Sykes A;Chatterjea D
通讯作者：
Chatterjea D
DOI：
10.1155/2012/130802
发表时间：
2012
期刊：
Evidence-based complementary and alternative medicine : eCAM
影响因子：
--
作者：
Ben H;Li L;Rong PJ;Jin ZG;Zhang JL;Li YH;Li X
通讯作者：
Li X