HPV type concordance in sexual couples determines the effect of condoms on regression of flat penile lesions.
HPV type concordance in sexual couples determines the effect of condoms on regression of flat penile lesions.
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DOI：
10.1038/sj.bjc.6602524
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发表时间：
2005-04-25
影响因子：
8.8
通讯作者：
中科院分区：
文献类型：
--
作者：
我们先前在一项随机临床试验中证实，宫颈上皮内瘤变（CIN）女性的男性性伴侣中，使用避孕套的男性与不使用避孕套的男性相比，阴茎扁平病变的消退时间更短。为了进一步评估这一发现，我们研究了使用避孕套对扁平阴茎病变消退的影响是否取决于性伴侣中人乳头瘤病毒（HPV）类型一致性的存在，如通过GP 5 +/6+ PCR检测在宫颈和阴茎刮擦中确定的。一个包含时间依赖性协变量的考克斯模型显示，避孕套对一致性夫妇的扁平阴茎病变消退具有有益作用（风险比2.63，95%CI 1.07-6.48），但对不一致性夫妇则无此作用。当双方携带不同类型的HPV时，未发现避孕套的影响（风险比0.90，95%CI 0.27-2.96）。扁平阴茎病变的延迟消退与稳定的病变或在先前存在的病变周围部位出现新的阴茎病变相关，表明阴茎上皮再感染。我们的结论是，避孕套的使用阻止性HPV传播，防止再感染和发展新的阴茎病变的男性谁是易感的相同类型，目前在女性伴侣。
We earlier demonstrated, in a randomised clinical trial, that the regression time of flat penile lsions in male sexual partners of women with cervical intraepithelial neoplasia (CIN) was shorter in men who used condoms compared to those who did not. To further evaluate this finding, we examined whether the effect of condom use on the regression of flat penile lesions depends on the presence of human papillomavirus (HPV) type concordance in sexual couples, as determined in cervical and penile scrapes by GP5+/6+ PCR testing. A Cox model with time-dependent covariates showed a beneficial effect of condoms on regression of flat penile lesions in concordant couples (hazard ratio 2.63, 95% CI 1.07–6.48) but not in those who were nonconcordant. When both partners harboured different HPV types, no effect of condoms was found (hazard ratio 0.90, 95% CI 0.27–2.96). Delayed regression of flat penile lesions was associated with either stable lesions or with new penile lesions developing at sites surrounding pre-existing lesions suggesting reinfection of the penile epithelium. We conclude that condom use blocks sexual HPV transmission by preventing reinfection and development of new penile lesions in men who are susceptible to the same type as present in the female partner.
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