Mice infected with Mycobacterium tuberculosis are resistant to acute disease caused by secondary infection with SARS-CoV-2.
Mice infected with Mycobacterium tuberculosis are resistant to acute disease caused by secondary infection with SARS-CoV-2.
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DOI：
10.1371/journal.ppat.1010093
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发表时间：
2022-03
期刊：
影响因子：
6.7
通讯作者：
Robinson RT
中科院分区：
文献类型：
--
作者：
Rosas Mejia O;Gloag ES;Li J;Ruane-Foster M;Claeys TA;Farkas D;Wang SH;Farkas L;Xin G;Robinson RT
结核分枝杆菌(Mtb)和SARS-CoV-2(CoV2)是导致传染病死亡的主要原因。虽然Mtb和CoV2都会引起严重的、有时是致命的呼吸道感染，但Mtb感染及其相关的免疫反应对CoV2继发感染的影响尚不清楚。为了解决这个问题，我们应用了两种柯萨奇病毒19的小鼠模型，使用的是慢性感染结核分枝杆菌的小鼠。在两个模型系统中，感染结核分枝杆菌的小鼠对继发CoV2感染的病理后果具有抵抗力，并且CoV2感染不影响结核分枝杆菌的负担。对混合感染和单一感染的肺的单细胞RNA测序表明，结核分枝杆菌感染小鼠的抵抗力与病毒攻击时T和B细胞亚群的扩大有关。总而言之，这些数据表明，结核分枝杆菌感染以一种不利于CoV2生存的方式调节肺环境。结核分枝杆菌(Mtb)和SARS-CoV-2(CoV2)是引起肺部疾病的两种不同的微生物。我们报告了一个令人惊讶的观察结果，即结核分枝杆菌感染的小鼠对CoV2的二次感染具有抵抗力，而与肺T和B细胞扩张相关的结核分枝杆菌负荷和抵抗力没有影响。
Mycobacterium tuberculosis (Mtb) and SARS-CoV-2 (CoV2) are the leading causes of death due to infectious disease. Although Mtb and CoV2 both cause serious and sometimes fatal respiratory infections, the effect of Mtb infection and its associated immune response on secondary infection with CoV2 is unknown. To address this question we applied two mouse models of COVID19, using mice which were chronically infected with Mtb. In both model systems, Mtb-infected mice were resistant to the pathological consequences of secondary CoV2 infection, and CoV2 infection did not affect Mtb burdens. Single cell RNA sequencing of coinfected and monoinfected lungs demonstrated the resistance of Mtb-infected mice is associated with expansion of T and B cell subsets upon viral challenge. Collectively, these data demonstrate that Mtb infection conditions the lung environment in a manner that is not conducive to CoV2 survival. Mycobacterium tuberculosis (Mtb) and SARS-CoV-2 (CoV2) are distinct organisms which both cause lung disease. We report the surprising observation that Mtb-infected mice are resistant to secondary infection with CoV2, with no impact on Mtb burden and resistance associating with lung T and B cell expansion.
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影响因子：
7.3
作者：
Eggenhuizen PJ;Ng BH;Chang J;Fell AL;Cheong RMY;Wong WY;Gan PY;Holdsworth SR;Ooi JD
通讯作者：
Ooi JD
影响因子：
4.6
作者：
Lacedonia D;Scioscia G;Santomasi C;Fuso P;Carpagnano GE;Portacci A;Mastroianni F;Larizza G;Sabato E;Profilo E;Resta E;Foschino Barbaro MP;Resta O
通讯作者：
Resta O
DOI：
10.1016/j.tube.2020.102020
发表时间：
2021-01
期刊：
Tuberculosis (Edinburgh, Scotland)
影响因子：
--
作者：
Mousquer GT;Peres A;Fiegenbaum M
通讯作者：
Fiegenbaum M
影响因子：
3.7
作者：
Inoue K;Kashima S
通讯作者：
Kashima S
影响因子：
9.2
作者：
Coppola M;Jurion F;van den Eeden SJF;Tima HG;Franken KLMC;Geluk A;Romano M;Ottenhoff THM
通讯作者：
Ottenhoff THM