Beetroot supplementation in women enjoying exercise together (BEE SWEET): Rationale, design and methods.
Beetroot supplementation in women enjoying exercise together (BEE SWEET): Rationale, design and methods.
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一起享受运动的女性补充甜菜根（BEE SWEET）：原理、设计和方法。
DOI：
10.1016/j.conctc.2020.100693
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发表时间：
2021-03
影响因子：
1.5
通讯作者：
Carter SJ
中科院分区：
文献类型：
--
作者：
Baranauskas MN;Altherr CA;Gruber AH;Coggan AR;Raglin JS;Gupta SK;Carter SJ
随着年龄的增长，绝经后女性的残疾和心血管疾病(CVD)的发生率比男性更高。虽然习惯性运动训练是一种已知的增强男性和绝经前女性生理功能的策略，但与运动相关的适应在绝经后女性中往往是温和的。我们建议，在运动训练之前给予饮食硝酸盐(甜菜根汁)可能是改善绝经后女性活动能力和心脏代谢健康结果的可行方法。我们的随机、安慰剂对照研究旨在确定三个研究分支的功能流动性和内皮依赖性血管扩张变化的初步效应大小：仅锻炼(EX)、锻炼+安慰剂(EX+BPL)和锻炼+甜菜根(EX+BR)。36名绝经后妇女被招募为小组，其中实施集体锻炼，以促进社会支持和坚持为期8周的培训进程。在基线评估之后，参与者被随机分配到三个研究小组中的一个(n=12，每组)。干预后评估用于确定结果指标在干预前的变化，包括6分钟步行测试中覆盖的距离、步行经济性、肌肉速度和力量，以及通过血流介导的扩张确定的内皮依赖性血管扩张。可行性的衡量标准包括招募、保留、遵守运动处方、感觉到的运动会话困难和不良事件发生率。需要基于证据的翻译策略来优化绝经后妇女与运动训练相关的适应。研究结果将为更大规模的随机临床试验提供依据，以确定运动前饮用甜菜根汁是否是促进运动能力和降低心血管疾病风险的有效策略。
Postmenopausal women exhibit higher rates of disability and cardiovascular disease (CVD) with aging compared to men. Whereas habitual exercise training is a known strategy to enhance physiologic function in men and premenopausal women, exercise-related adaptations are often modest in postmenopausal women. We propose dietary nitrate (beetroot juice) administered prior to exercise training may be a feasible approach to improve mobility and cardio-metabolic health outcomes in postmenopausal women. Our randomized, placebo-controlled study aims to determine preliminary effects sizes for changes in functional mobility and endothelium-dependent vasodilation across three study arms: exercise only (EX), exercise + placebo (EX + PL), and exercise + beetroot (EX + BR). Thirty-six postmenopausal women are recruited in small cohorts wherein group exercise is implemented to facilitate social support and adherence to an 8-week training progression. Participants are randomized to one of three study arms (n = 12 per group) following baseline assessments. Post-intervention assessments are used to determine pre-post changes in outcome measures including distance covered during a 6 min walk test, walking economy, muscle speed and power, and endothelial-dependent vasodilation as determined by flow-mediated dilation. Measures of feasibility include recruitment, retention, adherence to exercise prescription, perceived exercise session difficulty, and adverse event rates. Evidence-based, translational strategies are needed to optimize exercise training-related adaptations in postmenopausal women. Findings will inform larger randomized clinical trials to determine if pre-exercise consumption of beetroot juice is an efficacious strategy to promote mobility and attenuate CVD disease risk.
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DOI：
10.1097/qai.0b013e3182a97c39
发表时间：
2013-11-01
期刊：
Journal of acquired immune deficiency syndromes (1999)
影响因子：
--
作者：
Gupta SK;Mi D;Moe SM;Dubé MP;Liu Z
通讯作者：
Liu Z
DOI：
10.1016/j.jchf.2015.12.013
发表时间：
2016-06
期刊：
JACC. Heart failure
影响因子：
--
作者：
Eggebeen J;Kim-Shapiro DB;Haykowsky M;Morgan TM;Basu S;Brubaker P;Rejeski J;Kitzman DW
通讯作者：
Kitzman DW
影响因子：
3.9
作者：
Berry, Michael J.;Justus, Nicholas W.;Miller, Gary D.
通讯作者：
Miller, Gary D.
影响因子：
2.5
作者：
Coggan, Andrew R.;Broadstreet, Seth R.;Peterson, Linda R.
通讯作者：
Peterson, Linda R.
影响因子：
1.4
作者：
Gelecek, Nihal;Ilcin, Nursen;Ormen, Murat
通讯作者：
Ormen, Murat