Lack of head sparing following third-trimester caloric restriction among Tanzanian Maasai.
Lack of head sparing following third-trimester caloric restriction among Tanzanian Maasai.
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DOI：
10.1371/journal.pone.0237700
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发表时间：
2020
期刊：
影响因子：
3.7
通讯作者：
Gonzalez PN
中科院分区：
文献类型：
--
作者：
Powell CD;Wilson WM;Olesaningo G;Manyama M;Jamniczky H;Spritz R;Cross JC;Lukowiak K;Hallgrimsson B;Gonzalez PN
怀孕期间减少食物摄入量是世界各地许多文化和宗教传统的一部分。人们对这种做法对胎儿生长发育的影响知之甚少。在这里，我们检查了马赛孕妇的饮食摄入模式，并评估了其对新生儿形态测量的影响。我们从坦桑尼亚北部的恩戈罗恩戈罗保护区 (NCA) 招募了 141 对母婴，并量化了怀孕期间母亲饮食的摄入量和变化。我们测量了出生时的体重 (BW) 和头围 (HC)。我们发现，马赛女性在妊娠晚期显着减少了饮食摄入量，从前两个三个月的平均每天 1601 大卡减少到最后三个月的平均每天 799 大卡。营养素减少的最大比例是碳水化合物。总体而言，NCA 样本中 40% 的 HC Z 分数比 WHO 标准低 2 个标准差以上。近三分之一的新生儿属于低出生体重（< 2500 克）。该队列中的 HC 相对于 BW 的值小于使用 WHO 标准预测的值。这与同时在城市环境中获得的坦桑尼亚出生队列形成鲜明对比，其中只有 12% 的婴儿体重过轻，只有两人的 HC Z 分数 < 2，并且 HC 相对于出生体重的比例大于使用 WHO 标准的预测值。 NCA 队列中令人惊讶的头部保护不足表明，妊娠晚期营养不良的影响需要在动物模型和人类群体中进行进一步研究，特别是因为低 HC 与长期健康结果呈负相关。
The reduction of food intake during pregnancy is part of many cultural and religious traditions around the world. The impact of such practices on fetal growth and development are poorly understood. Here, we examined the patterns of diet intake among Maasai pregnant women and assessed their effect on newborn morphometrics. We recruited 141 mother-infant pairs from Ngorongoro Conservation Area (NCA) in Northern Tanzania and quantified dietary intake and changes in maternal diet during pregnancy. We obtained measurements of body weight (BW) and head circumference (HC) at birth. We found that Maasai women significantly reduced their dietary intake during the third trimester, going from an average of 1601 kcal/day during the first two trimesters to 799 kcal/day in the final trimester. The greatest proportion of nutrient reduction was in carbohydrates. Overall, 40% of HC Z-scores of the NCA sample were more than 2 standard deviations below the WHO standard. Nearly a third of neonates classify as low birth weight (< 2500g). HC was smaller relative to BW in this cohort than predicted using the WHO standard. This contrasts markedly to a Tanzanian birth cohort obtained at the same time in an urban context in which only 12% of infants exhibited low weight, only two individuals had HC Z-scores < 2 and HC’s relative to birth weight were larger than predicted using the WHO standards. The surprising lack of head sparing in the NCA cohort suggests that the impact of third trimester malnutrition bears further investigation in both animal models and human populations, especially as low HC is negatively associated with long term health outcomes.
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影响因子：
2.9
作者：
Baker, Jack;Workman, Megan;Pearson, Osbjorn
通讯作者：
Pearson, Osbjorn
影响因子：
2
作者：
Borghi, E;de Onis, M;Martines, JC
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Martines, JC
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通讯作者：
PRYSEDAVIES, J
影响因子：
3.3
作者：
Barbeito-Andres, Jimena;Gleiser, Pablo M.;Gonzalez, Paula N.
通讯作者：
Gonzalez, Paula N.
影响因子：
0.9
作者：
Bishop, Elizabeth
通讯作者：
Bishop, Elizabeth