Overnight urinary melatonin levels in women with and without HIV: An observational cohort study.
Overnight urinary melatonin levels in women with and without HIV: An observational cohort study.
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DOI：
10.1002/brb3.3206
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发表时间：
2023-10
影响因子：
3.1
通讯作者：
French, Audrey L. L.
中科院分区：
文献类型：
--
作者：
Burgess, Helen J. J.;Weber, Kathleen M. M.;Morack, Ralph;Yohannes, Tsion;Xing, Jiaqian;Xue, Xiaonan;Gustafson, Deborah;Sharma, Anjali;Daubert, Elizabeth;Rogando, Andrea C. C.;French, Audrey L. L.
尽管抗逆转录病毒治疗显著改善了寿命和生活质量，但艾滋病毒感染者仍然比未感染艾滋病毒的人遭受更高的睡眠和昼夜节律紊乱以及炎症性疾病的负担。虽然褪黑激素是一种在睡眠和昼夜节律调节中起作用的激素，并具有抗炎特性，但尿褪黑激素代谢物的过夜浓度尚未在艾滋病毒感染者中报道。本研究的目的是比较年龄在35-70岁的HIV女性（n = 151）与无HIV女性（n = 147）的匹配对照组的夜间尿褪黑激素代谢物水平。所有的女性都戴着腕动监测仪，并完成了10天的日记，记录了睡眠时间和药物、药物或酒精的使用。参与者在监测期结束时收集了他们的过夜尿液。褪黑激素水平在感染或未感染艾滋病毒的女性之间没有差异，但超过40%的女性褪黑激素水平较低。较高的体重指数预示着较低的褪黑激素水平，而较低的褪黑激素水平与较低的睡眠效率相关，这一点通过腕动记录仪进行了评估。这些数据为探索内源性褪黑激素水平对患有和不患有艾滋病毒的老年妇女的炎症性疾病的纵向后果奠定了基础。未来的研究应该考虑使用补充褪黑激素来改善褪黑激素水平较低的女性的睡眠。虽然褪黑激素是一种在睡眠和昼夜节律调节中起作用的激素，并具有抗炎特性，但尿褪黑激素代谢物的过夜浓度尚未在艾滋病毒感染者中报道。本研究的目的是比较年龄在35-70岁的HIV女性（n = 151）与无HIV女性（n = 147）的匹配对照组的夜间尿褪黑激素代谢物水平。褪黑激素水平在感染或未感染艾滋病毒的女性之间没有差异，但超过40%的女性褪黑激素水平较低。
Despite significant improvements in longevity and quality of life associated with antiretroviral therapy, individuals with HIV still suffer from a higher burden of sleep and circadian disruption and inflammatory‐based diseases than individuals without HIV. While melatonin is a hormone that has a role in sleep and circadian regulation and has anti‐inflammatory properties, the overnight concentration of the urinary melatonin metabolite has not yet been reported in people with HIV. The aim of this study was to compare the overnight urinary melatonin metabolite levels in women aged 35–70 years with HIV (n = 151) to a well‐matched comparison group of women without HIV (n = 147). All women wore a wrist actigraphy monitor and completed daily diaries documenting sleep timing and use of medications and drugs or alcohol for 10 days. Participants collected their overnight urine near the end of the monitoring period. Melatonin levels did not differ between women with or without HIV, but more than 40% of women had low levels of melatonin. Higher body mass index predicted lower levels of melatonin, and lower levels of melatonin were associated with lower sleep efficiency as assessed with wrist actigraphy. These data lay the foundation for exploration of the longitudinal consequences of endogenous melatonin levels for inflammatory‐based diseases in aging women with and without HIV. Future studies should consider the use of supplemental melatonin to improve sleep in women with lower levels of melatonin. While melatonin is a hormone that has a role in sleep and circadian regulation and has anti‐inflammatory properties, the overnight concentration of the urinary melatonin metabolite has not yet been reported in people with HIV. The aim of this study was to compare the overnight urinary melatonin metabolite levels in women aged 35–70 years with HIV (n = 151) to a well‐matched comparison group of women without HIV (n = 147). Melatonin levels did not differ between women with or without HIV, but more than 40% of women had low levels of melatonin.
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