A roadmap for intestinal regeneration.

A roadmap for intestinal regeneration.
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DOI:
10.1387/ijdb.200227dq
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发表时间:
2021
期刊:
The International journal of developmental biology
影响因子:
--
通讯作者:
--
中科院分区:
其他
文献类型:
--
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丢失或受伤器官的再生是一个有趣的过程,其中发生许多细胞事件以形成新的结构。在肠重建过程中的这一过程的研究已经在棘皮动物中进行,特别是在海参中。以海参Holothuria glaberrima为研究模型,描述了再生过程中引发的许多细胞事件。最近的实验已经瞄准了这一过程背后的分子机制,这项任务已经被现在可用的新测序技术所简化。在这篇综述中,我们提出了涉及细胞过程的研究和已被确定为与肠道再生的早期事件相关的基因。我们还提出了正在进行的努力,以执行必要的功能研究,以建立所确定的基因的作用。研究的概要给出了迄今为止建立的再生过程的过程。
Regeneration of lost or injured organs is an intriguing process where numerous cellular events take place to form the new structure. Studies of this process during reconstitution of the intestine have been performed in echinoderms, particularly in holothurians. Many cellular events triggered during regeneration have been described using the sea cucumber Holothuria glaberrima as a research model. More recent experiments have targeted the molecular mechanism behind the process, a task that has been eased by the new sequencing technologies now available. In this review we present the studies involving cellular processes and the genes that have been identified to be associated with the early events of gut regeneration. We also present the ongoing efforts to perform functional studies necessary to establish the role(s) of the identified genes. A synopsis of the studies is given with the course of the regenerative process established so far.
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