Building Organs Using Tissue-Specific Microenvironments: Perspectives from a Bioprosthetic Ovary.

Building Organs Using Tissue-Specific Microenvironments: Perspectives from a Bioprosthetic Ovary.
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DOI:
10.1016/j.tibtech.2021.01.008
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发表时间:
2021-08
影响因子:
17.3
通讯作者:
Laronda MM
Laronda MM
中科院分区:
工程技术1区
文献类型:
--
作者:
Henning NFC;Jakus AE;Laronda MM

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Recent research in tissue engineering and regenerative medicine has elucidated the importance of the matrisome. The matrisome, effectively the skeleton of an organ, provides physical and biochemical cues that drive important processes such as differentiation, proliferation, migration, and cellular morphology. Leveraging the matrisome to control these and other tissue-specific processes will be key to developing transplantable bioprosthetics. In the ovary, the physical and biological properties of the matrisome have been implicated in controlling the important processes of follicle quiescence and folliculogenesis. This expanding body of knowledge is being applied in conjunction with new manufacturing processes to enable increasingly complex matrisome engineering, moving closer to emulating tissue structure, composition, and subsequent functions which can be applied to a variety of tissue engineering applications.
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