Functional Roles of Astrocyte Calcium Elevations: From Synapses to Behavior.

Functional Roles of Astrocyte Calcium Elevations: From Synapses to Behavior.
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星形胶质细胞钙高程的功能作用:从突触到行为。

DOI:
10.3389/fncel.2017.00427
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发表时间:
2017
影响因子:
5.3
通讯作者:
Oliveira JF
Oliveira JF
中科院分区:
医学2区
文献类型:
--
作者:
Guerra-Gomes S;Sousa N;Pinto L;Oliveira JF

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星形胶质细胞是调节突触传递和可塑性的基本角色。它们显示独特的形态和表型特征,允许监测和动态响应变化。星形细胞反应的特征之一是产生钙升高,这进一步影响下游的细胞过程。该领域的技术进步使得能够在空间和时间上量化和限定这些高程。然而,对大脑功能的影响仍然知之甚少。在这篇综述中,我们讨论了不同星形细胞钙事件对几个脑区功能影响的证据,以及它们对突触、回路和行为的影响。
Astrocytes are fundamental players in the regulation of synaptic transmission and plasticity. They display unique morphological and phenotypical features that allow to monitor and to dynamically respond to changes. One of the hallmarks of the astrocytic response is the generation of calcium elevations, which further affect downstream cellular processes. Technical advances in the field have allowed to spatially and to temporally quantify and qualify these elevations. However, the impact on brain function remains poorly understood. In this review, we discuss evidences of the functional impact of heterogeneous astrocytic calcium events in several brain regions, and their consequences in synapses, circuits, and behavior.
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