Emerging regulatory mechanisms and functions of autophagy in fish
Emerging regulatory mechanisms and functions of autophagy in fish
复制标题
鱼类自噬的新兴调控机制和功能
DOI：
10.1016/j.aquaculture.2019.734212
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发表时间：
2019-09
期刊：
影响因子：
4.5
通讯作者：
Likun Cheng
中科院分区：
文献类型：
--
作者：
Xiaojing Xia;Xin Wang;Wanhai Qin;Jinqing Jiang;Likun Cheng
自噬是一种大规模的亚细胞降解过程，真核细胞通过形成自噬体和循环利用细胞内物质来维持健康。这个特殊的过程是细胞存活、生长、分化、发育和体内平衡的重要机制。在过去的几十年里，对酵母和哺乳动物自噬的研究大大增加了我们对自噬及其与人类健康和疾病关系的了解。然而，我们对鱼类细胞自噬的了解有限。近年来，对鱼类细胞自噬的诱导、自噬相关基因的表达与调控、自噬在病原体感染条件下的作用等方面的研究取得了一定进展。特别是，转基因斑马鱼和斑马鱼细胞系被构建为模型，研究自噬在鱼类发育调节、抵抗病原体感染、脂质降解等生理和病理反应中的作用。了解鱼类自噬将有助于通过控制细胞自噬水平来改善鱼类健康，从而预防和治疗相关疾病。在这里，我们回顾了有关鱼类自噬的最新发现。
Autophagy is a bulk subcellular degradation process through which eukaryotic cells maintain health by forming autophagosomes and recycling intracellular substances. This particular process is an important mechanism for cell survival, growth, differentiation, development and homeostasis. Over the past few decades, studies on yeast and mammalian autophagy have greatly increased our understanding of autophagy and its relationship with human health and disease. However, our understanding of autophagy in fish cells is limited. Recent studies have made some progress in investigating the induction of autophagy in fish cells, the expression and regulation of autophagy-related genes, and the role of autophagy under conditions of pathogen infection. In particular, genetically modified zebrafish and zebrafish cell lines have been constructed as models to investigate the role of autophagy in developmental regulation, resistance to pathogen infection, lipid degradation and other physiological and pathological responses in fish. Understanding fish autophagy will aid in the prevention and treatment of related diseases by enabling the manipulation of autophagy levels in cells to improve fish health. Here, we review the most recent discoveries concerning autophagy in fish.
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影响因子：
3.6
作者：
Burdette DL;Seemann J;Orth K
通讯作者：
Orth K
影响因子：
82.9
作者：
通讯作者：
--
影响因子：
13.3
作者：
R. Thomé;H. Santos;F. P. Arantes;Fabricio F. T. Domingos;N. Bazzoli;E. Rizzo
通讯作者：
R. Thomé;H. Santos;F. P. Arantes;Fabricio F. T. Domingos;N. Bazzoli;E. Rizzo
黑鱼水泡病毒通过补充三羧酸循环繁殖需要谷氨酰胺
影响因子：
3.8
作者：
Sun Lindan;Yi Lizhu;Zhang Chi;Liu Xiaodan;Feng Shuangshuang;Chen Wenjie;Lan Jiangfeng;Zhao Lijuan;Tu Jiagang;Lin Li
通讯作者：
Lin Li
斑马鱼是一种了解自噬及其在神经疾病中的作用的模型。
DOI：
10.1016/j.bbadis.2011.01.004
发表时间：
2011-04
影响因子：
6.2
作者：
Fleming, Angeleen;Rubinsztein, David C.
通讯作者：
Rubinsztein, David C.