Association between asthma and risk of developing obstructive sleep apnea.
Association between asthma and risk of developing obstructive sleep apnea.
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DOI：
10.1001/jama.2014.17822
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发表时间：
2015-01-13
影响因子：
120.7
通讯作者：
Peppard, Paul E.
中科院分区：
文献类型：
--
作者：
Teodorescu, Mihaela;Barnet, Jodi H.;Hagen, Erika W.;Palta, Mari;Young, Terry B.;Peppard, Paul E.
阻塞性睡眠呼吸暂停（OSA）在哮喘患者中更常见;哮喘是否与OSA的发展有关尚不清楚。探讨哮喘与阻塞性睡眠呼吸暂停发作的关系。基于人群的前瞻性流行病学研究（威斯康星州睡眠队列）。从1988年开始，成年参与者从威斯康星州的国家雇员中随机抽样招募，每隔4年参加一次夜间多导睡眠图研究。在2013年3月之前的多导睡眠图研究中评估了哮喘和协变量信息。通过两项基线多导睡眠图研究确定为无OSA（呼吸暂停低通气指数<5起事件/小时且未接受治疗）且至少进行了一项额外多导睡眠图研究的参与者包括在内。547名参与者（52%为女性;平均[SD]基线年龄= 50 [8]岁）提供了1105个4年随访间隔。自我报告的医生诊断的哮喘的存在和持续时间的评估。使用重复测量Poisson回归估计哮喘的存在和持续时间与OSA（呼吸暂停低通气指数≥ 5或气道正压通气治疗）和OSA伴习惯性日间嗜睡的4年发病率的相关性，并调整混杂因素。81名哮喘参与者中有22名（27% [95%CI =17%-37%]）在首次观察的4年随访期间发生了OSA事件，而466名无哮喘参与者中有75例OSA事件（16% [95%CI，13%-19%]）。使用所有4年的时间间隔，哮喘参与者在167个4年的时间间隔中经历了45例OSA事件（27% [95%CI，20%-34%]）和无哮喘的参与者在938个4年间隔期间经历了160例OSA事件（17% [95%CI，15%-19%]）;相应的校正相对风险为1.39（95%CI，1.06-1.82），控制了性别、年龄、基线和体重指数变化以及其他因素。哮喘还与新发OSA伴习惯性嗜睡相关（相对危险度：2.72 [95%CI，1.26-5.89]，p=0.04）。哮喘持续时间与OSA事件（相对风险：哮喘持续时间每增加5年1.07 [95%CI，1.02-1.13]，p=0.01）和OSA事件伴习惯性嗜睡（相对风险：1.18 [95%CI，1.07-1.31]，p=0.02）相关。哮喘与新发OSA的风险增加相关。有必要对哮喘患者进行定期OSA评估。
Obstructive sleep apnea (OSA) is more common among patients with asthma; whether asthma is associated with the development of OSA is unknown. To examine the prospective relationship of asthma with incident OSA. Population-based prospective epidemiology study (the Wisconsin Sleep Cohort). Beginning in 1988, adult participants were recruited from a random sample of Wisconsin state employees to attend overnight polysomnography studies at 4-year intervals. Asthma and covariate information were assessed during polysomnography studies through March 2013. Participants identified as free of OSA (apnea-hypopnea index<5 events/hr and not treated) by two baseline polysomnography studies and that had at least one additional polysomnography study were included. 547 participants (52% women; mean [SD] baseline age = 50 [8] years) provided 1105 4-year follow-up intervals. Questionnaire-assessed presence and duration of self-reported physician-diagnosed asthma. The associations of presence and duration of asthma with 4-year incidences of both OSA (apnea-hypopnea index ≥ 5 or positive airway pressure treatment) and OSA concomitant with habitual daytime sleepiness were estimated using repeated-measures Poisson regression, adjusting for confounders. Twenty-two out of 81 (27% [95% CI=17%–37%]) participants with asthma experienced incident OSA over their first observed 4-year follow-up interval compared to 75 incident cases of OSA among 466 participants without asthma (16% [95% CI, 13%–19%]). Using all 4-year intervals, participants with asthma experienced 45 incident OSA cases during 167 4-year intervals (27% [95% CI, 20%–34%]) and participants without asthma experienced 160 incident OSA cases during 938 4-year intervals (17% [95% CI, 15%–19%]); the corresponding adjusted relative risk was 1.39 (95% CI, 1.06–1.82), controlling for sex, age, baseline and change in body mass index, and other factors. Asthma was also associated with new-onset OSA with habitual sleepiness (relative risk: 2.72 [95% CI, 1.26–5.89], p=0.04). Asthma duration was related to both incident OSA (relative risk: 1.07 per 5-year increment in asthma duration [95% CI, 1.02–1.13], p=0.01) and incident OSA with habitual sleepiness (relative risk: 1.18 [95% CI, 1.07–1.31], p=0.02). Asthma was associated with increased risk of new-onset OSA. Studies investigating the value of periodic OSA evaluation in patients with asthma are warranted.
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影响因子：
9.6
作者：
Teodorescu, Mihaela;Polomis, David A.;Jarjour, Nizar N.
通讯作者：
Jarjour, Nizar N.
影响因子：
9.6
作者：
Knuiman, Matthew;James, Alan;Bartholomew, Helen
通讯作者：
Bartholomew, Helen
DOI：
10.1164/rccm.2202005
发表时间：
2002-08-15
影响因子：
24.7
作者：
Reid, MB;Lännergren, J;Westerblad, H
通讯作者：
Westerblad, H
影响因子：
3.3
作者：
BALLARD, RD;IRVIN, CG;WHITE, DP
通讯作者：
WHITE, DP
影响因子：
5
作者：
Peppard, Paul E.;Young, Terry;Hla, Khin Mae
通讯作者：
Hla, Khin Mae