Review article: vitamin D and inflammatory bowel diseases.
Review article: vitamin D and inflammatory bowel diseases.
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DOI：
10.1111/apt.12553
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发表时间：
2014-01
影响因子：
7.6
通讯作者：
Ananthakrishnan AN
中科院分区：
文献类型：
--
作者：
Mouli VP;Ananthakrishnan AN
维生素D与骨代谢有关。维生素D的免疫作用越来越受到关注。回顾支持维生素D在炎症性肠病中作用的证据。使用术语“克罗恩病”、“溃疡性结肠炎”和“维生素D”在PubMed上进行了全面检索。维生素D缺乏在IBD患者（16-95%）中很常见，包括最近诊断出疾病的患者。证据支持维生素D在IBD中的免疫作用。在动物模型中，缺乏维生素D会增加对DSS结肠炎的易感性，而1，25（OH）2D 3会改善这种结肠炎。一项前瞻性队列研究发现，低预测维生素D水平与CD风险增加相关。有限的数据还表明，低维生素D水平和疾病活动增加之间存在关联，特别是在克罗恩病中。在一个大型队列中，维生素D缺乏（<20 ng/mL）与CD患者手术风险（OR 1.8，95% CI 1.2 - 2.5）以及CD（OR 2.1，95% CI 1.6 - 2.7）和UC（OR 2.3，95% CI 1.7 - 3.1）患者住院风险增加相关。一项随机对照试验表明，与安慰剂相比，补充维生素D可能与克罗恩病患者复发频率降低有关（13% vs. 29%，p = 0.06）。越来越多的流行病学证据表明，维生素D缺乏在IBD的发展中起作用，并影响疾病的严重程度。维生素D在IBD患者中可能的治疗作用值得继续研究。
Vitamin D is traditionally associated with bone metabolism. The immunologic effects of vitamin D have increasingly come into focus. To review the evidence supporting a role of vitamin D in inflammatory bowel diseases. A comprehensive search was performed on PubMed using the terms “crohn’s disease” “ulcerative colitis” and “vitamin D” Vitamin D deficiency is common in patients with IBD (16–95%) including those with recently diagnosed disease. Evidence supports immunologic role of vitamin D in IBD. In animal models, deficiency of vitamin D increases susceptibility to DSS colitis while 1,25(OH)2D3 ameliorates such colitis. One prospective cohort study found low predicted vitamin D levels to be associated with an increased risk of CD. Limited data also suggests an association between low vitamin D levels and increased disease activity, particularly in Crohn’s disease. In a large cohort, vitamin D deficiency (< 20ng/mL) was associated with increased risk of surgery (OR 1.8, 95% CI 1.2 – 2.5) in CD and hospitalizations in both CD (OR 2.1, 95% CI 1.6 – 2.7) and UC (OR 2.3, 95% CI 1.7 – 3.1). A single randomized controlled trial demonstrated that vitamin D supplementation may be associated with reduced frequency of relapses in patients with Crohn’s disease compared to placebo (13% vs. 29%, p = 0.06). There is growing epidemiological evidence to suggest a role for vitamin D deficiency in the development of IBD and also its influence on disease severity. The possible therapeutic role of vitamin D in patients with IBD merits continued investigation.
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影响因子：
1.2
作者：
Atia, Antwan;Murthy, Ravindra;Peiris, Alan N.
通讯作者：
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影响因子：
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影响因子：
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作者：
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DOI：
10.1097/mpg.0b013e31826a105d
发表时间：
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影响因子：
2.9
作者：
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通讯作者：
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维生素 D 介导的单核细胞抗菌反应的变阻调节。
DOI：
10.4049/jimmunol.0803736
发表时间：
2009-04-01
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Adams JS;Ren S;Liu PT;Chun RF;Lagishetty V;Gombart AF;Borregaard N;Modlin RL;Hewison M
通讯作者：
Hewison M