Obstructive sleep apnea: the new cardiovascular disease. Part I: Obstructive sleep apnea and the pathogenesis of vascular disease.

Obstructive sleep apnea: the new cardiovascular disease. Part I: Obstructive sleep apnea and the pathogenesis of vascular disease.
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DOI:
10.1007/s10741-008-9112-z
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发表时间:
2009-09
影响因子:
4.6
通讯作者:
Hayes, Don, Jr.
Hayes, Don, Jr.
中科院分区:
医学2区
文献类型:
--
作者:
Khayat, Rami;Patt, Brian;Hayes, Don, Jr.

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阻塞性睡眠呼吸暂停(OSA)越来越被认为是一种新的心血管危险因素。OSA与高血压、左心室功能障碍、冠状动脉疾病和中风的发病机制有关。OSA通过其独特的间歇性缺氧模式发挥其负面的心血管后果。内皮功能障碍、氧化应激和炎症都是OSA的后果,与OSA患者的心血管疾病发病机制中的间歇性缺氧和关键途径直接相关。本文就阻塞性睡眠呼吸暂停患者血管功能障碍的机制及其对心血管疾病的影响进行综述。
Obstructive sleep apnea (OSA) is increasingly recognized as a novel cardiovascular risk factor. OSA is implicated in the pathogenesis of hypertension, left ventricular dysfunction, coronary artery disease and stroke. OSA exerts its negative cardiovascular consequences through its unique pattern of intermittent hypoxia. Endothelial dysfunction, oxidative stress, and inflammation are all consequences of OSA directly linked to intermittent hypoxia and critical pathways in the pathogenesis of cardiovascular disease in patients with OSA. This review will discuss the known mechanisms of vascular dysfunction in patients with OSA and their implications for cardiovascular disease.
DOI: 10.1161/01.cir.0000015507.29953.38
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