Computerized cognitive remediation therapy effects on resting state brain activity and cognition in schizophrenia.
Computerized cognitive remediation therapy effects on resting state brain activity and cognition in schizophrenia.
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计算机认知矫正疗法对精神分裂症静息态大脑活动和认知的影响
DOI：
10.1038/s41598-017-04829-9
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发表时间：
2017-07-06
影响因子：
4.6
通讯作者：
Tan S
中科院分区：
文献类型：
--
作者：
Fan F;Zou Y;Tan Y;Hong LE;Tan S
本研究旨在测试为期8周的计算机化认知矫正疗法（CCRT）训练如何改变精神分裂症患者静息态大脑功能活动并改善其认知功能。招募了27名精神分裂症患者，并随机分为两组：CCRT组或常规治疗（TAU）组。CCRT组在8周内接受了40次计算机化认知训练。在处理速度方面（连线测验：F = 8.14，P = 0.01）存在显著的治疗组×时间交互作用，在问题解决方面有趋势（迷宫测验：P = 0.06）。事后检验显示，从基线到治疗结束，CCRT组在这两项认知评估中的得分显著提高，而TAU组则没有。对于静息态大脑功能活动，在内侧前额叶皮质（mPFC）/前扣带回皮质（ACC）和脑干脑桥区域发现了显著的组×时间交互作用效应。事后检验显示，CCRT组而非TAU组的mPFC/ACC活动显著增加。在这项小样本研究中，计算机化认知矫正疗法被证明即使在静息状态下也能增强精神分裂症患者的mPFC/ACC活动并改善其认知功能。如果能重复验证，这种社区和诊所可及的疗法可能有助于精神分裂症患者的认知矫正工作。
This study aimed to test how an 8-week training using computerized cognitive remediation therapy (CCRT) would modify resting brain functional activity and improve cognitive function in patients with schizophrenia. Twenty-seven patients with schizophrenia were recruited and randomized into two groups: CCRT or treatment-as-usual (TAU). The CCRT group received 40 sessions of computerized cognitive training over an eight-week period. There was a significant treatment group × time interaction on the processing speed (trail making test: F = 8.14, P = 0.01) and a trend in problem solving (mazes test: P = 0.06). Post-hoc tests showed that CCRT but not TAU significantly improved scores from baseline to end-of-treatment on these two cognitive assessments. For the resting brain functional activity, significant group × time interaction effect was found in the medial prefrontal cortex (mPFC)/anterior cingulate cortex (ACC) and brainstem pons region. Post-hoc tests showed that there was significant increased activity in the mPFC/ACC in CCRT but not TAU group. In this small sample study, computerized cognitive remediation therapy is shown to enhance mPFC/ACC activity even at resting state and improve cognitive function in patients with schizophrenia. If replicated, this community and clinic accessible therapy may assist cognitive remediation effort for people with schizophrenia.
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影响因子：
3.2
作者：
Díez-Cirarda M;Ojeda N;Peña J;Cabrera-Zubizarreta A;Lucas-Jiménez O;Gómez-Esteban JC;Gómez-Beldarrain MÁ;Ibarretxe-Bilbao N
通讯作者：
Ibarretxe-Bilbao N
影响因子：
2.8
作者：
Degen, Christina;Schroeder, Johannes
通讯作者：
Schroeder, Johannes
影响因子：
--
作者：
Hogarty, GE;Flesher, S;Zoretich, R
通讯作者：
Zoretich, R
影响因子：
17.7
作者：
Callicott, JH;Mattay, VS;Weinberger, DR
通讯作者：
Weinberger, DR
影响因子：
11.3
作者：
Cavallaro, Roberto;Anselmetti, Simona;Smeraldi, Enrico
通讯作者：
Smeraldi, Enrico