Fluid-structure interaction modelling of a positive-displacement Total Artificial Heart.
Fluid-structure interaction modelling of a positive-displacement Total Artificial Heart.
复制标题
阳性置换总人工心脏的流体结构相互作用模型。
DOI：
10.1038/s41598-023-32141-2
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发表时间：
2023-04-14
影响因子：
4.6
通讯作者：
Fraser, Katharine H.
中科院分区：
文献类型：
--
作者：
Bornoff, Joseph;Najar, Azad;Fresiello, Libera;Finocchiaro, Thomas;Perkins, Ina Laura;Gill, Harinderjit;Cookson, Andrew N.;Fraser, Katharine H.
对于那些患有终末期双心室心力衰竭的患者，如果心脏移植不是一个可行的选择，全人工心脏（TAH）可以用作移植器械的桥梁。Realheart TAH是一种四腔人工心脏，采用模仿自体心脏的正排量泵送技术，通过一对双叶机械心脏瓣膜产生脉动流。这项工作的目的是创建一种用于模拟容积式血泵中血液动力学的方法，使用具有流体-结构相互作用的计算流体动力学来消除对预先存在的体外瓣膜运动数据的需要，然后使用它来研究Realheart TAH在一系列操作条件下的性能。该装置在Ansys Fluent中以60、80、100和120 bpm的泵送速率和19、21、23和25 mm的冲程长度进行了五个循环的模拟。该装置的运动部件使用重叠网格方法进行离散，在流体和结构求解器之间使用新型的混合弱-强耦合算法，并且使用定制的可变时间步进方案来最大化计算效率和准确性。一个两个元素的Windkessel模型近似的生理压力响应的出口。使用混合心血管模拟器将瞬态流出体积流速和压力结果与体外实验进行比较，结果显示出良好的一致性，流速和压力的最大均方根误差分别为15%和5%。模拟心室冲洗，并显示随着心输出量增加而增加，在120 bpm 25 mm下四个周期后最大值为89%。还测量了随时间推移的剪切应力分布，显示在心输出量为7 L/min时，不超过%的总容量超过150 Pa。该研究表明，该模型在广泛的工作点范围内既准确又稳健，将使未来对当前和未来几代Realheart TAH进行快速有效的研究成为可能。
For those suffering from end-stage biventricular heart failure, and where a heart transplantation is not a viable option, a Total Artificial Heart (TAH) can be used as a bridge to transplant device. The Realheart TAH is a four-chamber artificial heart that uses a positive-displacement pumping technique mimicking the native heart to produce pulsatile flow governed by a pair of bileaflet mechanical heart valves. The aim of this work was to create a method for simulating haemodynamics in positive-displacement blood pumps, using computational fluid dynamics with fluid–structure interaction to eliminate the need for pre-existing in vitro valve motion data, and then use it to investigate the performance of the Realheart TAH across a range of operating conditions. The device was simulated in Ansys Fluent for five cycles at pumping rates of 60, 80, 100 and 120 bpm and at stroke lengths of 19, 21, 23 and 25 mm. The moving components of the device were discretised using an overset meshing approach, a novel blended weak–strong coupling algorithm was used between fluid and structural solvers, and a custom variable time stepping scheme was used to maximise computational efficiency and accuracy. A two-element Windkessel model approximated a physiological pressure response at the outlet. The transient outflow volume flow rate and pressure results were compared against in vitro experiments using a hybrid cardiovascular simulator and showed good agreement, with maximum root mean square errors of 15% and 5% for the flow rates and pressures respectively. Ventricular washout was simulated and showed an increase as cardiac output increased, with a maximum value of 89% after four cycles at 120 bpm 25 mm. Shear stress distribution over time was also measured, showing that no more than % of the total volume exceeded 150 Pa at a cardiac output of 7 L/min. This study showed this model to be both accurate and robust across a wide range of operating points, and will enable fast and effective future studies to be undertaken on current and future generations of the Realheart TAH.
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DOI：
10.1016/j.healun.2009.05.034
发表时间：
2010-01
期刊：
The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation
影响因子：
--
作者：
Fukamachi K;Horvath DJ;Massiello AL;Fumoto H;Horai T;Rao S;Golding LA
通讯作者：
Golding LA
影响因子：
8.3
作者：
Bragazzi, Nicola Luigi;Zhong, Wen;Dai, Haijiang
通讯作者：
Dai, Haijiang
DOI：
10.1080/10255842.2023.2199903
发表时间：
2023-04-05
影响因子：
1.6
作者：
Bornoff，J.;Gill，H. S.;Fraser，K. H.
通讯作者：
Fraser，K. H.
影响因子：
2.4
作者：
Kobayashi, Mariko;Horvath, David J.;Golding, Leonard A. R.
通讯作者：
Golding, Leonard A. R.
影响因子：
1.3
作者：
Akutsu, Toshinosuke;Matsumoto, Akira
通讯作者：
Matsumoto, Akira