Response properties of spiking and non-spiking brain neurons mirror pulse interval selectivity.
Response properties of spiking and non-spiking brain neurons mirror pulse interval selectivity.
复制标题
DOI：
10.3389/fncel.2022.1010740
复制
发表时间：
2022
影响因子：
5.3
通讯作者：
中科院分区：
文献类型：
--
作者：
在双点场蟋蟀种特异性鸣叫的听觉脉冲模式识别是基于延迟线和重合检测网络，建立在大脑中只有5个听觉神经元的活动和突触连接。为了更详细地了解网络和神经活动随时间的动态变化，我们分析了这些神经元对测试模式的响应特性，其中脉冲持续时间保持恒定，而特定脉冲间隔的持续时间系统地改变。我们证实，上行中间神经元AN 1和本地中间神经元LN 2复制的脉冲模式的结构，但在短脉冲间隔有限的分辨率，进一步明显的下游神经反应。在非尖峰延迟线中间神经元LN 5在长脉冲间隔期间，在35-70 ms的时间过程中发展完全成熟的反弹电位。LN 5还揭示了其膜电位的整体增加，该膜电位被调谐到呼叫歌曲脉冲模式的啁啾。这可以通过驱动重合检测器LN 3的活动来对模式识别过程做出贡献，并且可以指示延迟线神经元LN 5的另一功能。LN 3和特征检测器LN 4的活动与趋声性行为的调谐相匹配，并表现出呼叫歌曲脉冲模式的越来越稀疏的编码，这在特征检测器LN 4的响应中是明显的。该电路揭示了听觉模式识别的基本机制，并展示了神经元编码的原理。
In the bispotted field cricket auditory pulse pattern recognition of the species-specific calling song is based on a delay-line and coincidence detection network, established by the activity and synaptic connections of only 5 auditory neurons in the brain. To obtain a more detailed understanding of the network and the dynamic of the neural activity over time we analyzed the response properties of these neurons to test patterns, in which the pulse duration was kept constant while the duration of specific pulse intervals was systematically altered. We confirm that the ascending interneuron AN1 and the local interneuron LN2 copy the structure of the pulse pattern, however with limited resolution at short pulse intervals, further evident in downstream neural responses. In the non-spiking delay-line interneuron LN5 during long pulse intervals full-blown rebound potentials develop over a time course of 35–70 ms. LN5 also reveals an overall increase in its membrane potential tuned to chirps of the calling song pulse pattern. This may contribute to the pattern recognition process by driving the activity of the coincidence-detector LN3 and may indicate a further function of the delay-line neuron LN5. The activity of LN3 and of the feature detector LN4 match the tuning of the phonotactic behavior and demonstrate an increasingly sparse coding of the calling song pulse patterns as evident in the response of the feature detector LN4. The circuitry reveals a fundamental mechanism of auditory pattern recognition and demonstrates a principle of neuronal coding.
登录
查看更多内容
影响因子：
2.5
作者：
Kostarakos, Konstantinos;Hedwig, Berthold
通讯作者：
Hedwig, Berthold
DOI：
10.1098/rspb.2017.0745
发表时间：
2017-05-31
期刊：
Proceedings. Biological sciences
影响因子：
--
作者：
Hedwig B;Sarmiento-Ponce EJ
通讯作者：
Sarmiento-Ponce EJ
影响因子：
2.8
作者：
Hedwig, B;Poulet, JEA
通讯作者：
Poulet, JEA
DOI：
10.1523/jneurosci.2998-09.2010
发表时间：
2010-03-31
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Goaillard JM;Taylor AL;Pulver SR;Marder E
通讯作者：
Marder E
影响因子：
64.8
作者：
Hedwig, B;Poulet, JFA
通讯作者：
Poulet, JFA