Review of the distribution of Kaposi's sarcoma-associated herpesvirus (KSHV) in Africa in relation to the incidence of Kaposi's sarcoma.
Review of the distribution of Kaposi's sarcoma-associated herpesvirus (KSHV) in Africa in relation to the incidence of Kaposi's sarcoma.
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DOI：
10.1038/sj.bjc.6600745
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发表时间：
2003-01-13
影响因子：
8.8
通讯作者：
中科院分区：
文献类型：
--
作者：
在人类免疫缺陷病毒（HIV）感染之前的几年里，卡波西肉瘤的发病率在非洲大陆各地差异很大，它是一种主要影响男性的疾病。相比之下，这里回顾的证据表明，致病病毒卡波西肉瘤相关疱疹病毒（KSHV）在许多非洲国家普遍存在，包括卡波西肉瘤在艾滋病毒之前几乎不为人知的地方，并且在女性和男性中同样常见。因此，卡波西肉瘤在艾滋病毒传播之前在非洲的地理分布及其作为影响男性的疾病的优势并不是KSHV分布的简单反映。自从艾滋病毒在非洲流行以来，卡波西肉瘤在妇女中变得相对更常见，在以前罕见但KSHV流行的国家以及已经很常见的国家，发病率有所增加。这些变化表明卡波西肉瘤病因学中的其他（尚不清楚）因素可能在没有并发HIV感染的情况下发挥最大作用。
In the years before human immunodeficiency virus (HIV) infection, the incidence of Kaposi's sarcoma varied markedly across the African continent, and it was a disease primarily affecting men. In contrast, the evidence reviewed here shows that the causal virus–Kaposi's sarcoma associated herpesvirus (KSHV)–is prevalent in many African countries, including places where Kaposi's sarcoma was almost unknown before HIV, and that it is as common in women as in men. Therefore, the geographical distribution of Kaposi's sarcoma in Africa before the spread of HIV and its predominance as a disease affecting men are not a simple reflection of the distribution of KSHV. Since the epidemic of HIV in Africa, Kaposi's sarcoma has become relatively more frequent in women, and the incidence has increased in countries where it was previously rare, but where KSHV is prevalent, as well as in countries where it was already common. These changes point to a role for other (as yet unknown) factors in the aetiology of Kaposi's sarcoma that may have the most effect in the absence of concurrent HIV infection.
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影响因子：
14.5
作者：
Hayward, GS
通讯作者：
Hayward, GS
影响因子：
3.8
作者：
Kasolo, FC;Mpabalwani, E;Gompels, UA
通讯作者：
Gompels, UA
影响因子：
8.8
作者：
Enbom, M;Tolfvenstam, T;Linde, A
通讯作者：
Linde, A
影响因子：
8.8
作者：
Cook-Mozaffari, P;Newton, R;Beral, V;Burkitt, D P
通讯作者：
Burkitt, D P
影响因子：
6.4
作者：
BASSETT, MT;CHOKUNONGA, E;PARKIN, DM
通讯作者：
PARKIN, DM