Inhibition of the Prefrontal Projection to the Nucleus Accumbens Enhances Pain Sensitivity and Affect.
Inhibition of the Prefrontal Projection to the Nucleus Accumbens Enhances Pain Sensitivity and Affect.
复制标题
抑制前额叶向伏核的投射可增强疼痛敏感性和影响力
DOI：
10.3389/fncel.2018.00240
复制
发表时间：
2018
影响因子：
5.3
通讯作者：
Wang J
中科院分区：
文献类型：
--
作者：
Zhou H;Martinez E;Lin HH;Yang R;Dale JA;Liu K;Huang D;Wang J
调节急性或慢性疼痛的皮质机制仍然知之甚少。前额叶皮层（PFC）对感觉和情感行为起着至关重要的控制作用。最近的研究表明，激活从PFC到延髓核（NAc）的投射，这是大脑奖赏回路中的一个重要通路，可以产生对疼痛的感觉和情感成分的抑制。然而，目前还不清楚这条回路是否内源性参与疼痛调节。为了回答这个问题，我们使用光遗传学策略破坏了这个回路。我们在PFC的锥体神经元中表达盐视紫红质，然后选择性地抑制从这些神经元到NAc核心中的神经元的轴突投射。我们的研究结果表明，抑制PFC或其投射到NAc，加剧感觉和情感症状的急性疼痛的幼稚大鼠。在慢性神经病理性疼痛模型中，这种皮质纹状体通路的抑制也增加了伤害性敏感性和厌恶反应。最后，皮质纹状体抑制导致了与慢性疼痛相似的厌恶表型。这些结果有力地表明，从PFC到NAc的投射在内源性疼痛调节中起着重要作用，并且其损伤有助于慢性疼痛的病理学。
Cortical mechanisms that regulate acute or chronic pain remain poorly understood. The prefrontal cortex (PFC) exerts crucial control of sensory and affective behaviors. Recent studies show that activation of the projections from the PFC to the nucleus accumbens (NAc), an important pathway in the brain’s reward circuitry, can produce inhibition of both sensory and affective components of pain. However, it is unclear whether this circuit is endogenously engaged in pain regulation. To answer this question, we disrupted this circuit using an optogenetic strategy. We expressed halorhodopsin in pyramidal neurons from the PFC, and then selectively inhibited the axonal projection from these neurons to neurons in the NAc core. Our results reveal that inhibition of the PFC or its projection to the NAc, heightens both sensory and affective symptoms of acute pain in naïve rats. Inhibition of this corticostriatal pathway also increased nociceptive sensitivity and the aversive response in a chronic neuropathic pain model. Finally, corticostriatal inhibition resulted in a similar aversive phenotype as chronic pain. These results strongly suggest that the projection from the PFC to the NAc plays an important role in endogenous pain regulation, and its impairment contributes to the pathology of chronic pain.
登录
查看更多内容
影响因子：
16.2
作者：
Baliki, Marwan N.;Geha, Paul Y.;Fields, Howard L.;Apkarian, A. Vania
通讯作者：
Apkarian, A. Vania
影响因子：
5.3
作者：
Apkarian, AV;Sosa, Y;Gitelman, DR
通讯作者：
Gitelman, DR
影响因子：
11.2
作者：
DeFelice, Milena;Eyde, Nathan;Dodick, David;Dussor, Gregory O.;Ossipov, Michael H.;Fields, Howard L.;Porreca, Frank
通讯作者：
Porreca, Frank
影响因子：
16.2
作者：
Arnsten AF;Wang MJ;Paspalas CD
通讯作者：
Paspalas CD
影响因子：
7.4
作者：
Bourquin, Anne-Frederique;Sueveges, Maria;Decosterd, Isabelle
通讯作者：
Decosterd, Isabelle