Attention-induced deactivations in very low frequency EEG oscillations: differential localisation according to ADHD symptom status.
Attention-induced deactivations in very low frequency EEG oscillations: differential localisation according to ADHD symptom status.
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DOI：
10.1371/journal.pone.0017325
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发表时间：
2011-03-08
期刊：
影响因子：
3.7
通讯作者：
Sonuga-Barke EJ
中科院分区：
文献类型：
--
作者：
Broyd SJ;Helps SK;Sonuga-Barke EJ
默认模式网络（DMN）以相干甚低频（VLF）脑振荡为特征。这种VLF谱的认知意义尚不清楚，部分原因是血氧水平依赖（BOLD）信号的时间限制性质。以前，我们已经确定了一个头皮位置的VLF脑电图网络，它具有DMN的许多特征。在这里，我们探讨了VLF脑电图的颅内来源，并检查了它们与DMN在高和低ADHD评分成人中的重叠。采用等距66通道电极蒙太奇对25名ADHD症状等级高的成年参与者和25名ADHD症状等级低的成年参与者在休息条件下和注意力要求埃里克森任务中进行DC-EEG记录。计算休息和任务条件下VLF频带（0.02 ~ 0.2 Hz）的VLF脑电功率，并比较高、低ADHD参与者的VLF脑电功率。使用sLORETA识别与注意诱导的VLF脑电图功率失活相关的脑源，并检查这些脑源与ADHD症状的关系。整个被试在休息状态和任务状态之间存在显著的VLF脑电失活。使用s-LORETA，这种失活的来源定位于内侧前额叶区，后扣带皮层/楔前叶和颞区。然而，高、低ADHD组的失活源不同：在低ADHD组中，注意力诱导的VLF脑电图失活在内侧前额叶区域最为显著，而在高ADHD组中，这种失活主要发生在颞叶。注意诱发的VLF脑电图失活有颅内来源，似乎与DMN重叠。此外，这些似乎与ADHD症状状态有关，高ADHD成人未能显着停用内侧前额叶区域，同时在颞叶中表现出显著的VLF脑电图功率衰减。
The default-mode network (DMN) is characterised by coherent very low frequency (VLF) brain oscillations. The cognitive significance of this VLF profile remains unclear, partly because of the temporally constrained nature of the blood oxygen-level dependent (BOLD) signal. Previously we have identified a VLF EEG network of scalp locations that shares many features of the DMN. Here we explore the intracranial sources of VLF EEG and examine their overlap with the DMN in adults with high and low ADHD ratings. DC-EEG was recorded using an equidistant 66 channel electrode montage in 25 adult participants with high- and 25 participants with low-ratings of ADHD symptoms during a rest condition and an attention demanding Eriksen task. VLF EEG power was calculated in the VLF band (0.02 to 0.2 Hz) for the rest and task condition and compared for high and low ADHD participants. sLORETA was used to identify brain sources associated with the attention-induced deactivation of VLF EEG power, and to examine these sources in relation to ADHD symptoms. There was significant deactivation of VLF EEG power between the rest and task condition for the whole sample. Using s-LORETA the sources of this deactivation were localised to medial prefrontal regions, posterior cingulate cortex/precuneus and temporal regions. However, deactivation sources were different for high and low ADHD groups: In the low ADHD group attention-induced VLF EEG deactivation was most significant in medial prefrontal regions while for the high ADHD group this deactivation was predominantly localised to the temporal lobes. Attention-induced VLF EEG deactivations have intracranial sources that appear to overlap with those of the DMN. Furthermore, these seem to be related to ADHD symptom status, with high ADHD adults failing to significantly deactivate medial prefrontal regions while at the same time showing significant attenuation of VLF EEG power in temporal lobes.
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DOI：
10.1073/pnas.0504136102
发表时间：
2005-07-05
影响因子：
11.1
作者：
Fox, MD;Snyder, AZ;Raichle, ME
通讯作者：
Raichle, ME
影响因子：
1.7
作者：
Cao, Qingjiu;Zang, Yufeng;Wang, Yufeng
通讯作者：
Wang, Yufeng
影响因子：
3.2
作者：
Lawrence, NS;Ross, TJ;Stein, EA
通讯作者：
Stein, EA
影响因子：
3.2
作者：
Greicius, MD;Menon, V
通讯作者：
Menon, V
DOI：
10.1073/pnas.0601417103
发表时间：
2006-09-12
影响因子：
11.1
作者：
Damoiseaux, J. S.;Rombouts, S. A. R. B.;Beckmann, C. F.
通讯作者：
Beckmann, C. F.