Hypothalamic-pituitary-adrenal axis and behavioral dysfunction following early binge-like prenatal alcohol exposure in mice.
Hypothalamic-pituitary-adrenal axis and behavioral dysfunction following early binge-like prenatal alcohol exposure in mice.
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DOI：
10.1016/j.alcohol.2015.01.005
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发表时间：
2015-05
期刊：
影响因子：
2.3
通讯作者：
Sulik, Kathleen K.
中科院分区：
文献类型：
--
作者：
Wieczorek, Lindsay;Fish, Eric W.;O'Leary-Moore, Shonagh K.;Parnell, Scott E.;Sulik, Kathleen K.
胎儿酒精谱系障碍 (FASD) 的一系列缺陷包括持续的行为问题，其中焦虑和抑郁是最常见的两个问题。先前对啮齿动物 FASD 模型的研究表明，下丘脑-垂体-肾上腺 (HPA) 轴结构和/或功能的干扰可能是某些产前酒精（乙醇）暴露 (PAE) 诱发的行为异常的基础。之前的研究表明，仅限于妊娠早期（即小鼠妊娠日 [GD]7；相当于人类受精后第三周）的母体酒精治疗可能会导致下丘脑、垂体和其他控制压力和行为反应不可或缺的前脑区域的结构异常。目前的研究旨在进一步检查早期产前酒精损伤的后遗症，特别关注成年小鼠 HPA 轴相关的功能变化。这项研究的结果表明，GD7 PAE 会导致小鼠 HPA 轴功能障碍，在 15 分钟的束缚应激暴露后，雄性和雌性小鼠的皮质酮 (CORT) 和促肾上腺皮质激素 (ACTH) 水平分别升高。在急性注射 2.0 g/kg 酒精后，雄性小鼠的 CORT 水平也有所升高，而雌性则表现出 ACTH 水平下降。此外，分析表明，GD7 PAE 后雌性小鼠的焦虑样行为减少，但雄性小鼠的焦虑样行为增加。总的来说，这项研究的结果表明，妊娠早期接触酒精会以性别二态性的方式改变长期 HPA 轴活动和行为。
The range of defects that fall within fetal alcohol spectrum disorder (FASD) includes persistent behavioral problems, with anxiety and depression being two of the more commonly reported issues. Previous studies of rodent FASD models suggest that interference with hypothalamic-pituitary-adrenal (HPA) axis structure and/or function may be the basis for some of the prenatal alcohol (ethanol) exposure (PAE)-induced behavioral abnormalities. Included among the previous investigations are those illustrating that maternal alcohol treatment limited to very early stages of pregnancy (i.e., gestational day [GD]7 in mice; equivalent to the third week post-fertilization in humans) can cause structural abnormalities in areas such as the hypothalamus, pituitary gland, and other forebrain regions integral to controlling stress and behavioral responses. The current investigation was designed to further examine the sequelae of prenatal alcohol insult at this early time period, with particular attention to HPA axis-associated functional changes in adult mice. The results of this study reveal that GD7 PAE in mice causes HPA axis dysfunction, with males and females showing elevated corticosterone (CORT) and adrenocorticotropic hormone (ACTH) levels, respectively, following a 15-min restraint stress exposure. Males also showed elevated CORT levels following an acute alcohol injection of 2.0 g/kg, while females displayed blunted ACTH levels. Furthermore, analysis showed that anxiety-like behavior was decreased after GD7 PAE in female mice, but was increased in male mice. Collectively, the results of this study show that early gestational alcohol exposure in mice alters long-term HPA axis activity and behavior in a sexually dimorphic manner.
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影响因子：
8
作者：
Fryer, Susanna L.;McGee, Christie L.;Mattson, Sarah N.
通讯作者：
Mattson, Sarah N.
影响因子：
--
作者：
COULTER, CL;LEECH, RW;BRUMBACK, RA
通讯作者：
BRUMBACK, RA
DOI：
10.1111/j.1530-0277.2009.01132.x
发表时间：
2010-04
期刊：
Alcoholism, clinical and experimental research
影响因子：
--
作者：
Hellemans KG;Verma P;Yoon E;Yu WK;Young AH;Weinberg J
通讯作者：
Weinberg J
影响因子：
3.3
作者：
Jacobson, SW;Bihun, JT;Chiodo, LM
通讯作者：
Chiodo, LM
DOI：
10.1016/0736-5748(92)90016-s
发表时间：
1992-08-01
影响因子：
1.8
作者：
KOTCH, LE;SULIK, KK
通讯作者：
SULIK, KK