3D printing for the design and fabrication of polymer-based gradient scaffolds.
3D printing for the design and fabrication of polymer-based gradient scaffolds.
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DOI：
10.1016/j.actbio.2017.03.030
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发表时间：
2017-07-01
影响因子：
9.7
通讯作者：
Fisher JP
中科院分区：
文献类型：
--
作者：
Bracaglia LG;Smith BT;Watson E;Arumugasaamy N;Mikos AG;Fisher JP
为了准确模拟天然组织环境，组织工程支架通常需要高度受控且多样化的三维 (3D) 架构和几何线索显示。组织工程中的增材制造使得开发模仿天然组织结构的复杂支架成为可能。因此，以前无法实现或不可重复的建筑细节现在可以纳入有序和有组织的方法中，进一步推进传递给与支架相互作用的细胞的结构和化学线索。这种对环境的控制使工程师能够解锁高度依赖于天然组织复杂的异质环境的细胞机器。最近对支架内物理和化学梯度结合的研究表明，整合这些特征可以改善组织工程结构的功能。本综述涵盖了通过增材制造将梯度融入聚合物支架的技术的最新进展，并评估了这些技术的成功。如本文所述，为了最好地复制不同的组织类型，人们必须认识到可用于创建这些梯度支架的截然不同类型的制造技术。我们回顾了可用于制造具有异质特性的支架的各种类型的增材制造技术，并讨论了成功表征它们的方法。
To accurately mimic the native tissue environment, tissue engineered scaffolds often need to have a highly controlled and varied display of three-dimensional (3D) architecture and geometrical cues. Additive manufacturing in tissue engineering has made possible the development of complex scaffolds that mimic the native tissue architectures. As such, architectural details that were previously unattainable or irreproducible can now be incorporated in an ordered and organized approach, further advancing the structural and chemical cues delivered to cells interacting with the scaffold. This control over the environment has given engineers the ability to unlock cellular machinery that is highly dependent upon the intricate heterogeneous environment of native tissue. Recent research into the incorporation of physical and chemical gradients within scaffolds indicates that integrating these features improves the function of a tissue engineered construct. This review covers recent advances on techniques to incorporate gradients into polymer scaffolds through additive manufacturing and evaluate the success of these techniques. As covered here, to best replicate different tissue types, one must be cognizant of the vastly different types of manufacturing techniques available to create these gradient scaffolds. We review the various types of additive manufacturing techniques that can be leveraged to fabricate scaffolds with heterogeneous properties and discuss methods to successfully characterize them.
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影响因子：
14
作者：
Akar, Banu;Jiang, Bin;Brey, Eric M.
通讯作者：
Brey, Eric M.
影响因子：
9
作者：
Hockaday LA;Kang KH;Colangelo NW;Cheung PY;Duan B;Malone E;Wu J;Girardi LN;Bonassar LJ;Lipson H;Chu CC;Butcher JT
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Butcher JT
影响因子：
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作者：
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通讯作者：
Seppala, Jukka V.
影响因子：
4.1
作者：
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通讯作者：
Cray, James J.
DOI：
10.1007/s001700300035
发表时间：
2003-01-01
影响因子：
3.4
作者：
Chua, CK;Leong, KF;Chua, SW
通讯作者：
Chua, SW