The biological activity of alpha-mangostin, a larvicidal botanic mosquito sterol carrier protein-2 inhibitor.
The biological activity of alpha-mangostin, a larvicidal botanic mosquito sterol carrier protein-2 inhibitor.
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DOI：
10.1603/me09160
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发表时间：
2010-03
影响因子：
2.1
通讯作者：
Lan Q
中科院分区：
文献类型：
--
作者：
Larson RT;Lorch JM;Pridgeon JW;Becnel JJ;Clark GG;Lan Q
通过高通量杀虫剂筛选，从山竹中提取的α-芒果糖苷被鉴定为蚊虫甾醇载体蛋白-2抑制物。测定了α-芒果苷对6种蚊虫3龄幼虫的杀灭活性，半数致死浓度范围为0.84ppm~2.90ppm。在半场条件下，测定了α-芒果苷的残留杀幼虫活性。结果表明，在全光照下，α-芒果苷在水中具有光解作用，半衰期为53min。研究了α-芒果苷对主要解毒酶P450、谷胱甘肽S转移酶和酯酶活性的影响。结果表明，α-芒果苷显著提高幼虫体内P450和谷胱甘肽S转移酶的活性，而抑制酯酶的活性。本文研究了α-芒果苷对幼年大鼠的毒性，在80 mg/kg剂量下未见明显不良反应。这是首次对蚊子体内α-芒果蛋白的生物活性进行的多方面研究。结果表明，α-芒果苷可能是一种开发新型有机蚊子杀幼剂的先导化合物。
α-Mangostin derived from mangosteen was identified as a mosquito sterol carrier protein-2 inhibitor via high throughput insecticide screening. α-Mangostin was tested for its larvicidal activity against third instar larvae of six mosquito species, and the median lethal concentration values range from 0.84 to 2.90 ppm. The residual larvicidal activity of α-mangostin was examined under semifield conditions. The results indicated that α-mangostin was photolytic with a half-life of 53 min in water under full sunlight exposure. The effect of α-mangostin on activities of major detoxification enzymes such as P450, glutathione S-transferase, and esterase was investigated. The results showed that α-mangostin significantly elevated activities of P450 and glutathione S-transferase in larvae, whereas it suppressed esterase activity. Toxicity of α-mangostin against young rats was studied, and there was no detectable adverse effect at dosages as high as 80 mg/kg. This is the first multifaceted study of the biological activity of α-mangostin in mosquitoes. The results suggest that α-mangostin may be a lead compound for the development of a new organically based mosquito larvicide.
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影响因子：
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