Hormonal contraceptive use and prevalence of premenstrual symptoms in a multiethnic Canadian population.
Hormonal contraceptive use and prevalence of premenstrual symptoms in a multiethnic Canadian population.
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DOI：
10.1186/s12905-017-0450-7
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发表时间：
2017-09-26
期刊：
影响因子：
--
通讯作者：
El-Sohemy A
中科院分区：
文献类型：
--
作者：
Jarosz AC;Jamnik J;El-Sohemy A
荷尔蒙避孕药的使用可能与一些经前症状的减少有关，然而，证据仍然不明确。本研究的目的是调查种族和荷尔蒙避孕药使用与经前症状之间的关系。参与多伦多营养基因组学和健康研究的1,102名妇女提供了关于她们经前症状和激素避孕药使用的数据。症状的严重程度被分类为无、轻度、中度或重度。在总人口和主要民族中确定了经前症状的患病率。使用Logistic回归分析来确定种族与经前症状患病率之间的关系。使用Logistic回归来确定激素避孕药的使用和经前症状之间的关系，并调整了种族和其他协变量。个别症状的发生率各不相同，最常见的报告是抽筋(75%)、腹胀(75%)、情绪波动(73%)、食欲增加(%)和粉刺(62%)。抽筋的患病率在不同种族之间有所不同，东亚人报告的患病率低于高加索人和南亚人(p<0.05)。激素避孕药的使用与中重度抽筋(0.82，0.72-0.93)、笨拙(0.22，0.07-0.73)、困惑(0.22，0.09-0.54)和独处欲望(0.45，0.28-0.73)的RR(95%CI)较低相关。激素避孕药的使用与轻度经前症状的风险无关。使用激素避孕药与焦虑、腹胀、情绪波动、食欲增加、粉刺、疲劳、性欲、抑郁、恶心、头痛和失眠症状无关。这项研究表明，东亚人经历经前痉挛的风险可能较低，使用激素避孕药与经历许多(但不是全部)中/重度经前症状的风险较低相关。
Hormonal contraceptive use may be associated with a reduction in some premenstrual symptoms, however, the evidence remains equivocal. The objectives of the present study were to investigate the associations between ethnicity and hormonal contraceptive use with premenstrual symptoms. One thousand one hundred two women participating in the Toronto Nutrigenomics and Health Study provided data on their premenstrual symptoms and hormonal contraceptive use. Severity of symptoms was classified as none, mild, moderate, or severe. Prevalence of premenstrual symptoms was determined in the total population and among major ethnic groups. Logistic regressions were used to determine the association between ethnicity and prevalence of premenstrual symptoms. Logistic regressions were used to determine the associations between hormonal contraceptive use, and premenstrual symptoms, adjusting for ethnicity and other covariates. Prevalence of individual symptoms varied, and the most commonly reported were cramps (75%), bloating (75%), mood swings (73%), increased appetite (64%), and acne (62%). Prevalence of cramps differed between ethnic groups with East Asians reporting a lower prevalence than Caucasians and South Asians (p < 0.05). Use of hormonal contraceptives was associated with a lower RR (95% CI) of experiencing moderate/severe: cramps (0.82, 0.72-0.93), clumsiness (0.22, 0.07-0.73), confusion (0.22, 0.09-0.54) and desire to be alone (0.45, 0.28-0.73). Hormonal contraceptive use was not associated with the risk of premenstrual symptoms at mild severity. Hormonal contraceptive use was not associated with symptoms of anxiety, bloating, mood swings, increased appetite, acne, fatigue, sexual desire, depression, nausea, headache and insomnia. This study demonstrates that East Asians may be at a lower risk of experiencing premenstrual cramps and that hormonal contraceptive use is associated with a lower risk of experiencing many, but not all, premenstrual symptoms at moderate/severe severity.
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DOI：
10.1186/1472-6874-14-52
发表时间：
2014-03-29
期刊：
BMC women's health
影响因子：
--
作者：
Tolossa FW;Bekele ML
通讯作者：
Bekele ML
DOI：
10.1016/s0002-9378(03)00927-x
发表时间：
2003-12-01
影响因子：
9.8
作者：
Joffe, H;Cohen, LS;Harlow, BL
通讯作者：
Harlow, BL
影响因子：
7.1
作者：
Garcia-Bailo, Bibiana;Brenner, Darren R.;El-Sohemy, Ahmed
通讯作者：
El-Sohemy, Ahmed
影响因子：
5.8
作者：
Legro, Richard S.;Pauli, Jaimey G.;Dodson, William C.
通讯作者：
Dodson, William C.
影响因子：
3.4
作者：
Ozsungur, Stephen;Brenner, Darren;El-Sohemy, Ahmed
通讯作者：
El-Sohemy, Ahmed