Antigen-presenting cells in the induction of contact hypersensitivity in mice: evidence that Langerhans cells are sufficient but not required.
Antigen-presenting cells in the induction of contact hypersensitivity in mice: evidence that Langerhans cells are sufficient but not required.
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抗原呈递细胞在诱导小鼠接触超敏反应中的作用：证据表明朗格汉斯细胞是足够的，但不是必需的。
DOI：
10.1111/1523-1747.ep12284018
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发表时间：
1989
期刊：
影响因子：
--
通讯作者：
Sreilein,JW
中科院分区：
文献类型：
--
作者：
Sreilein,JW
某些遗传上确定的小鼠品系被证明对低剂量紫外线B辐射诱导接触性超敏反应的作用具有抗性，这一事实的一种解释是，紫外线B抗性小鼠具有通过皮肤呈递抗原的第二途径--一种不依赖于表皮朗格汉斯细胞并且超出紫外线B光的损伤作用范围的途径。作为一个推论，紫外线-B敏感的小鼠将被认为是在这一途径的缺陷。采用了几种实验策略来确定是否需要朗格汉斯细胞来诱导由表皮细胞施加的半抗原引起的接触性超敏反应。结果表明，胶带剥离的皮肤支持接触性超敏反应的诱导，而手术切除的半抗原涂敷的皮肤在1小时内的应用程序不允许接触性超敏反应的发展。由于前者选择性地消除表皮朗格汉斯细胞，而后者删除朗格汉斯细胞和真皮抗原呈递细胞，我们得出结论，无论是朗格汉斯细胞或真皮细胞足以提供抗原呈递在诱导接触性超敏反应。当将大量半抗原涂敷在表皮上时，或者当半抗原皮下注射或涂敷在皮下组织上时，也会导致接触超敏反应，这表明接触超敏反应的诱导不需要皮肤细胞提供抗原加工和呈递。原因的结论是，在生理情况下诱导接触性超敏反应的表皮半抗原应用主要依赖于抗原呈递能力的表皮（朗格汉斯细胞）和真皮细胞。
One explanation for the fact that certain genetically defined strains of mice prove to be resistant to effects of low dose ultraviolet B radiation on the induction of contact hypersensitivity is that ultraviolet B resistant mice possess a second pathway for antigen presentation through the skin—a pathway that is independent of epidermal Langerhans cells and beyond the reach of the damaging effects of ultraviolet B Light. As a corollary, ultraviolet-B susceptible mice would be expected to be deficient in this pathway. Several experimental strategies were employed to determine whether Langerhans cells are required for the induction of contact hypersensitivity by epicutaneously applied hapten. The results reveal that tape-stripped skin supports the induction of contact hypersensitivity, whereas surgical excision of hapten-painted skin within 1 h of application fails to permit the development of contact hypersensitivity. Because the former selectively eliminates epidermal Langerhans cells while the latter deletes both Langerhans cells and dermal antigen-presenting cells, we conclude that either Langerhans cells or dermal cells are sufficient to provide antigen presentation in the induction of contact hypersensitivity. When large amounts of hapten are painted epicutaneously, or when hapten is injected subcutaneously or painted on sub-dermal tissues, contact hypersensitivity also results, indicating that induction of contact hypersensitivity does not require that antigen processing and presentation be provided by cutaneous cells. Reasons are presented for concluding that under physiologic circumstances induction of contact hypersensitivity by epicutaneous hapten application relies primarily upon the antigen-presenting capabilities of epidermal (Langerhans cells) and dermal cells.
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影响因子：
6.5
作者：
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影响因子：
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DOI：
--
发表时间：
1989
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
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通讯作者：
Streilein,JW
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DOI：
10.1111/1523-1747.ep12482453
发表时间：
1981
期刊：
The Journal of investigative dermatology
影响因子：
--
作者：
Streilein,JW;Bergstresser,PR
通讯作者：
Bergstresser,PR
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影响因子：
6.5
作者：
E. Tschachler;G. Schuler;J. Hutterer;H. Leibl;K. Wolff;G. Stingl
通讯作者：
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