Viscoelastic response of human skin to low magnitude physiologically relevant shear.
Viscoelastic response of human skin to low magnitude physiologically relevant shear.
复制标题
人皮肤对低生理相关剪切的粘弹性反应。
DOI：
10.1016/j.jbiomech.2008.06.008
复制
发表时间：
2008-08-28
影响因子：
2.4
通讯作者：
Morgan, Jeffrey
中科院分区：
文献类型：
--
作者：
Holt, Brian;Tripathi, Anubhav;Morgan, Jeffrey
经皮植入物是一系列穿透皮肤的装置，并且由于装置周围的皮肤密封不是最佳的，所以所有装置都遭受相同的感染问题。造成这个问题的原因是皮肤/器械界面的机械不连续性，导致应力集中和微创伤，长期破坏形成的任何密封。在本文中，我们已经量化了人体皮肤在生理相关频率的低幅度剪切载荷下的力学行为。使用应力控制流变仪，我们已经分别在全皮肤和仅真皮上在0.5%和0.04%应变下在0.628至75.39rad/s之间进行了等温（37°C）频率响应实验。还进行了5和10 Pa剪切载荷的步进应力实验以及应变扫描实验（6.28rad/s）。对整个人皮肤和去除表皮的皮肤（仅真皮）进行测量。在低频率（0.628至10 rad/s）下，模量仅轻微地依赖于频率，模量的近似幂律缩放G′ ~ G″ ~ ωβ，对于整个皮肤产生β = 0.05，对于仅真皮样品产生β = 0.16。步进应力实验揭示了三个不同的阶段。中间阶段包括弹性“振铃”（阻尼振荡），这提供了新的见解，并可以拟合到一个数学模型。频率和阶跃应力响应数据表明，表皮提供弹性刚度和真皮提供粘弹性的整个皮肤样品。因此，整个皮肤表现出应变硬化，而真皮只表现出应力软化下阶跃应力条件。从接近经皮植入物的慢性机械环境的低幅度剪切载荷和频率获得的数据应有助于设计具有改善的皮肤密封的器械。
Percutaneous implants are a family of devices that penetrate the skin and all suffer from the same problems of infection because the skin seal around the device is not optimal. Contributing to this problem is the mechanical discontinuity of the skin/device interface leading to stress concentrations and micro-trauma that chronically breaks any seal that forms. In this paper, we have quantified the mechanical behavior of human skin under low-magnitude shear loads over physiological relevant frequencies. Using a stress-controlled rheometer, we have performed isothermal (37°C) frequency response experiments between 0.628 to 75.39rad/s at 0.5% and 0.04% strain on whole skin and dermis-only, respectively. Step-stress experiments of 5 and 10Pa shear loads were also conducted as were strain sweep tests (6.28rad/s). Measurements were made of whole human skin and skin from which the epidermis was removed (dermis-only). At low frequencies (0.628 to 10rad/s), the moduli are only slightly frequency dependent, with approximate power-law scaling of the moduli, G′ ~ G″ ~ ωβ, yielding β = 0.05 for whole skin and β = 0.16 for dermis-only samples. Step-stress experiments revealed three distinct phases. The intermediate phase included elastic “ringing” (damped oscillation) which provided new insights and could be fit to a mathematical model. Both the frequency and step stress response data suggests that the epidermis provides elastic rigidity and dermis provides viscoelasticity to the whole skin samples. Hence, whole skin exhibited strain hardening while the dermis-only demonstrated stress softening under step-stress conditions. The data obtained from the low magnitude shear loads and frequencies that approximate the chronic mechanical environment of a percutaneous implant should aid in the design of a device with an improved skin seal.
登录
查看更多内容
DOI：
10.1159/000211681
发表时间：
1969-01-01
期刊：
GERONTOLOGIA
影响因子：
--
作者：
GRAHAME, R;HOLT, PJL
通讯作者：
HOLT, PJL
影响因子：
21.3
作者：
Ma, LL;Yamada, S;Coulombe, PA
通讯作者：
Coulombe, PA
影响因子：
14
作者：
Paquay, YCGJ;deRuijter, JE;Jansen, JA
通讯作者：
Jansen, JA
影响因子：
2.4
作者：
Danion, F;Varraine, E;Pailhous, J
通讯作者：
Pailhous, J
影响因子：
2.2
作者：
Silver, FH;Freeman, JW;DeVore, D
通讯作者：
DeVore, D