Strong Positive Selection in Aedes aegypti and the Rapid Evolution of Insecticide Resistance.
Strong Positive Selection in Aedes aegypti and the Rapid Evolution of Insecticide Resistance.
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DOI：
10.1093/molbev/msad072
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发表时间：
2023-04-04
影响因子：
10.7
通讯作者：
Schrider, Daniel R.
中科院分区：
文献类型：
--
作者：
Love, R. Rebecca;Sikder, Josh R.;Vivero, Rafael J.;Matute, Daniel R.;Schrider, Daniel R.
埃及伊蚊传播引起登革热、黄热病、寨卡病毒和基孔肯雅热的病原体，对热带地区的公共卫生构成严重威胁。几十年的工作已经照亮了人工智能的许多方面。埃及伊蚊的生物学和全球种群结构，并已确定了抗药性基因；然而，Ae的大小和重复性质。埃及伊蚊的基因组限制了我们在这种蚊子中检测正选择的能力。结合来自哥伦比亚的新的全基因组序列和来自非洲和美洲的公开数据，我们在Ae中识别了多个强有力的候选选择性扫描。埃及伊蚊，其中许多与抗药性有关或与抗药性有关的基因重叠。我们在三个美国队列中研究了电压门控钠通道基因，并找到了哥伦比亚连续选择性扫描的证据。最近的扫描包括一个中频单倍型，其中包含四个候选的抗药性突变，在哥伦比亚样本中，这些突变彼此之间处于近乎完美的连锁不平衡状态。我们推测，这种单倍型在未来几年可能会继续在频率上迅速增加，并可能在地理上传播。这些结果扩展了我们对该物种杀虫剂抗药性进化的了解，并增加了越来越多的证据表明Ae。埃及伊蚊具有广泛的基因组能力，能够迅速适应以杀虫剂为基础的媒介控制。
Aedes aegypti vectors the pathogens that cause dengue, yellow fever, Zika virus, and chikungunya and is a serious threat to public health in tropical regions. Decades of work has illuminated many aspects of Ae. aegypti's biology and global population structure and has identified insecticide resistance genes; however, the size and repetitive nature of the Ae. aegypti genome have limited our ability to detect positive selection in this mosquito. Combining new whole genome sequences from Colombia with publicly available data from Africa and the Americas, we identify multiple strong candidate selective sweeps in Ae. aegypti, many of which overlap genes linked to or implicated in insecticide resistance. We examine the voltage-gated sodium channel gene in three American cohorts and find evidence for successive selective sweeps in Colombia. The most recent sweep encompasses an intermediate-frequency haplotype containing four candidate insecticide resistance mutations that are in near-perfect linkage disequilibrium with one another in the Colombian sample. We hypothesize that this haplotype may continue to rapidly increase in frequency and perhaps spread geographically in the coming years. These results extend our knowledge of how insecticide resistance has evolved in this species and add to a growing body of evidence suggesting that Ae. aegypti has an extensive genomic capacity to rapidly adapt to insecticide-based vector control.
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人类的影响塑造了埃及埃及，登革热和黄热病蚊子的历史和最新进化。
DOI：
10.1111/evo.12281
发表时间：
2014-02
期刊：
Evolution; international journal of organic evolution
影响因子：
--
作者：
Brown JE;Evans BR;Zheng W;Obas V;Barrera-Martinez L;Egizi A;Zhao H;Caccone A;Powell JR
通讯作者：
Powell JR
影响因子：
56.9
作者：
Aubry, Fabien;Dabo, Stephanie;Lambrechts, Louis
通讯作者：
Lambrechts, Louis
影响因子：
4.9
作者：
Bennett, Kelly Louise;Shija, Fortunate;Walton, Catherine
通讯作者：
Walton, Catherine
影响因子：
1
作者：
Brennan, Sara A.;Grob, Ivy C.;Jiang, Yongxing
通讯作者：
Jiang, Yongxing
影响因子：
1.9
作者：
Brengues, C;Hawkes, NJ;Hemingway, J
通讯作者：
Hemingway, J