A longitudinal analysis of risk factors associated with central retinal vein occlusion.
A longitudinal analysis of risk factors associated with central retinal vein occlusion.
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DOI：
10.1016/j.ophtha.2012.07.080
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发表时间：
2013-02
期刊：
影响因子：
13.7
通讯作者：
Stein JD
中科院分区：
文献类型：
--
作者：
Stem MS;Talwar N;Comer GM;Stein JD
在美国纵向队列研究的不同患者群体中，确定与视网膜中央静脉阻塞（CRVO）相关的风险因素。所有年龄≥ 55岁、连续参加管理式护理网络至少≥2年且在2001-2009年期间接受过2次眼科护理的受益人，使用保险账单代码识别新患-确诊CRVO进行多变量考克斯回归以确定与CRVO发展相关的因素。在符合研究入选标准的494，165名入组者中，1，302名（0.26%）在5.4（±1.8）年内被诊断为CRVO。校正已知混杂因素后，黑人CRVO风险比白人高57%（HR = 1.57 [95% CI：1.25-1.98]），女性CRVO风险比男性低24%（HR = 0.76 [95% CI：0.67-0.85]）。卒中的诊断使CRVO风险增加45%（HR = 1.45 [95% CI：1.24-1.70]），高凝状态与CRVO风险增加146%相关（HR = 2.46 [95% CI：1.41-4.29]）。高血压（HTN）或糖尿病（DM）导致终末器官损害的个体相对于无这些疾病的个体，CRVO风险分别增加90%（HR = 1.90 [95%CI：1.50-2.41]）和53%（HR = 1.53 [95%CI：1.28-1.84]）。本研究证实HTN和血管疾病是CRVO的重要危险因素。我们还确定了黑人种族作为CRVO的预测因子，这在以前并没有得到很好的评价。此外，我们表明，与没有糖尿病的患者相比，患有糖尿病终末器官损伤的个体（即，“复杂”病例）的CRVO风险增加，而无并发症的DM患者的CRVO风险并未增加。这一发现可能为CRVO和DM之间相关性的文献中相互矛盾的报告提供了一个潜在的解释。来自此类分析的信息可用于创建风险计算器，以识别CRVO风险最大的个体。
To identify risk factors associated with central retinal vein occlusion (CRVO) among a diverse group of patients throughout the United States Longitudinal cohort study All beneficiaries age ≥ 55 years who were continuously enrolled in a managed care network for at least ≥2 years and who had 2 visits to an eye care provider from 2001–2009 Insurance billing codes were used to identify individuals with a newly-diagnosed CRVO. Multivariable Cox regression was performed to determine factors associated with CRVO development. Adjusted hazard ratios (HR) with 95% confidence intervals (CI) of being diagnosed with CRVO Of the 494,165 enrollees who met the study inclusion criteria, 1,302 (0.26%) were diagnosed with CRVO over 5.4 (±1.8) years. After adjustment for known confounders, blacks had a 57% increased risk of CRVO compared with whites (HR = 1.57 [95% CI: 1.25–1.98]) and females had a 24% decreased risk of CRVO compared with males (HR = 0.76 [95% CI: 0.67–0.85]). A diagnosis of stroke increased the hazard of CRVO by 45% (HR = 1.45 [95% CI: 1.24–1.70]) and hypercoagulable state was associated with a 146% increased CRVO risk (HR = 2.46 [95% CI: 1.41–4.29]). Individuals with end-organ damage from hypertension (HTN) or diabetes mellitus (DM) had a 90% (HR = 1.90 [95% CI: 1.50–2.41]) and 53% (HR = 1.53 [95% CI: 1.28–1.84]) increased risk of CRVO, respectively, relative to those without these conditions. This study confirms that HTN and vascular diseases are important risk factors for CRVO. We also identify black race as a predictor of CRVO that was not well-appreciated previously. Furthermore, we show that compared to patients without DM, individuals with end-organ damage from DM (i.e., “complicated” cases) have a heightened risk of CRVO, while those with uncomplicated DM are not at increased risk of CRVO. This finding may provide a potential explanation for the conflicting reports in the literature on the association between CRVO and DM. Information from analyses like this can be used to create a risk calculator to identify individuals at greatest risk for CRVO.
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影响因子：
6.7
作者：
Kuhli-Hattenbach, Claudia;Scharrer, Inge;Hattenbach, Lars-Olof
通讯作者：
Hattenbach, Lars-Olof
影响因子：
4.4
作者：
Cheung, Ning;Klein, Ronald;Wong, Tien Yin
通讯作者：
Wong, Tien Yin
DOI：
10.1034/j.1600-0420.1999.770602.x
发表时间：
1999-12-01
期刊：
ACTA OPHTHALMOLOGICA SCANDINAVICA
影响因子：
--
作者：
Kalayci, D;Gürgey, A;Hasiripi, H
通讯作者：
Hasiripi, H
影响因子：
13.7
作者：
Chan CK;Ip MS;Vanveldhuisen PC;Oden NL;Scott IU;Tolentino MJ;Blodi BA;SCORE Study Investigator Group
通讯作者：
SCORE Study Investigator Group
影响因子：
2.9
作者：
Glueck, Charles J.;Wang, Ping;Golnik, Karl
通讯作者：
Golnik, Karl