Perinatal THC exposure via lactation induces lasting alterations to social behavior and prefrontal cortex function in rats at adulthood.
Perinatal THC exposure via lactation induces lasting alterations to social behavior and prefrontal cortex function in rats at adulthood.
复制标题
DOI：
10.1038/s41386-020-0716-x
复制
发表时间：
2020-10
期刊：
影响因子：
--
通讯作者：
Manzoni OJJ
中科院分区：
文献类型：
--
作者：
Scheyer AF;Borsoi M;Pelissier-Alicot AL;Manzoni OJJ
大麻是世界上滥用最广泛的非法药物，妇女在怀孕期间和怀孕前后的消费量正在增加。以前，我们已经表明，大麻素暴露通过哺乳期在出生后早期破坏了早期发育轨迹的前额叶皮层成熟，并诱导行为异常的第一周的生活在男性和女性大鼠后代。在这里，我们调查了这种产后大麻素暴露对突触和行为参数的持久后果，在成年后代的109-四氢大麻酚（THC）治疗的母鼠。在成年期，这些围产期THC暴露的大鼠表现出社会歧视的缺陷，伴随着社会探索行为的整体增强。这些行为的改变进一步与多个异常的突触可塑性在前额叶皮层，包括失去内源性大麻素介导的长期抑郁症（LTD），失去长时程增强和增强mGlu 2/3-LTD。最后，基本参数的内在兴奋性在前额叶皮层锥体神经元同样改变了围产期THC暴露。因此，围产期THC暴露通过哺乳诱导持久的赤字行为和突触功能，持续到成年生活中的男性和女性后代。
Cannabis is the world’s most widely abused illicit drug and consumption amongst women during and surrounding the period of pregnancy is increasing. Previously, we have shown that cannabinoid exposure via lactation during the early postnatal period disrupts early developmental trajectories of prefrontal cortex maturation and induces behavioral abnormalities during the first weeks of life in male and female rat progeny. Here, we investigated the lasting consequences of this postnatal cannabinoid exposure on synaptic and behavioral parameters in the adult offspring of ∆9-tetrahydrocannabinol (THC)-treated dams. At adulthood, these perinatally THC-exposed rats exhibits deficits in social discrimination accompanied by an overall augmentation of social exploratory behavior. These behavioral alterations were further correlated with multiple abnormalities in synaptic plasticity in the prefrontal cortex, including lost endocannabinoid-mediated long-term depression (LTD), lost long-term potentiation and augmented mGlu2/3-LTD. Finally, basic parameters of intrinsic excitability at prefrontal cortex pyramidal neurons were similarly altered by the perinatal THC exposure. Thus, perinatal THC exposure via lactation induces lasting deficits in behavior and synaptic function which persist into adulthood life in male and female progeny.
登录
查看更多内容
影响因子：
4.7
作者：
Araque A;Castillo PE;Manzoni OJ;Tonini R
通讯作者：
Tonini R
影响因子：
7.2
作者：
Baker, Teresa;Datta, Palika;Hale, Thomas W.
通讯作者：
Hale, Thomas W.
影响因子：
8
作者：
Bertrand, Kerri A.;Hanan, Nathan J.;Chambers, Christina D.
通讯作者：
Chambers, Christina D.
影响因子：
3.4
作者：
Marsicano, G;Lutz, B
通讯作者：
Lutz, B
影响因子：
3
作者：
Borsoi, Milene;Manduca, Antonia;Manzoni, Olivier J.
通讯作者：
Manzoni, Olivier J.