Predictors of body composition and body energy changes in response to chronic overfeeding.
Predictors of body composition and body energy changes in response to chronic overfeeding.
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DOI：
10.1038/ijo.2013.77
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发表时间：
2014-02
影响因子：
4.9
通讯作者：
Tremblay, A.
中科院分区：
文献类型：
--
作者：
Bouchard, C.;Tchernof, A.;Tremblay, A.
我们以前已经表明，24名年轻的瘦男子（12对同卵双胞胎）进行了标准化的353兆焦耳（84 000千卡）的过度喂养协议超过100天表现出个体差异的体重和成分的增益。脂肪质量（FM）和去脂肪质量（FFM）的平均（± SD）增量分别为5.4 ± 1.9 kg和2.7 ± 1.5 kg，总身体能量（BE）增量为221 ± 75 MJ，占消耗能量盈余的63%。我们在这里报告了这些过度喂养引起的变化的最重要的基线相关性，目的是确定反应的生物标志物。基线时每千克体重的最大摄氧量与体重、FM和BE的增加呈负相关（所有p<0.05）。指示骨骼肌氧化电位的酶活性与FM和BE的增加相关（所有p<0.05）。对TRH刺激反应的基线TSH水平与FM与FFM比值的变化呈正相关（p<0.05）。血浆中硫酸雄烯二醇、脱氢表雄酮和17-羟基炔雌醇酮浓度与FM和BE的增重呈负相关（0.01<p<0.05），而雌酮水平与FFM增重呈负相关，而雄激素-葡萄糖醛酸苷与FFM增重呈正相关（p<0.05）。基线瘦素和腹部脂肪细胞大小与体重、FM和BE的增加呈正相关（p<0.05）。当与六个最高BE增益者相比时，六个最低增益者表现出较高的膳食热效应（TEM）和总睾酮、皮质醇、雌二醇、雄烯二酮和硫酸雄烯二醇的血浆水平（所有p<0.05）。总TEM、睾酮和硫酸雄烯二醇的高基线水平与较低的FM增加相关，而FT 4和雌酮的高基线水平在低FFM增加者中发现。虽然没有一个变量单独施加了压倒性的强烈影响过度喂养引起的变化，基线FFM，最大摄氧量，肌肉氧化能力，雄激素和瘦素水平是最一致的显着生物标志物的反应慢性过度喂养。
We have previously shown that 24 young lean men (12 pairs of identical twins) subjected to a standardized 353 MJ (84 000 kcal) overfeeding protocol over 100 days exhibited individual differences in body weight and composition gains. The mean (+SD) gains in fat mass (FM) and fat-free mass (FFM) were 5.4+1.9 kg and 2.7+1.5 kg for a total body energy (BE) gain of 221+75 MJ representing 63% of the energy surplus consumed. We report here on the most important baseline correlates of these overfeeding-induced changes with the aim of identifying biomarkers of the response. Baseline maximal oxygen uptake per kilogram body mass was negatively correlated with gains in weight, FM, and BE (all p<0.05). Enzyme activities indicative of skeletal muscle oxidative potential correlated with gains in FM and BE (all p<0.05). Baseline TSH levels in response to a TRH stimulation correlated positively with changes in FM-to-FFM ratio (p<0.05). Plasma concentrations of androstenediol-sulfate, dehydroepiandrosterone, and 17-hydroxy pregnenolone were negatively correlated with gains in FM and BE (0.01<p<0.05), while level of estrone was negatively and androsterone-glucoronide was positively correlated with FFM gains (p<0.05). Baseline leptin and abdominal fat cell size correlated positively with gains in weight, FM, and BE (p<0.05). When compared to the six highest BE gainers, the six lowest gainers exhibited higher thermic effect of a meal (TEM) and plasma levels of total testosterone, cortisol, estradiol, androstenedione, and androstenediol-sulfate (all p<0.05). High baseline levels of total TEM, testosterone, and androstenediol-sulfate were associated with lower FM gains whereas high baseline levels of FT4 and estrone were found in low-FFM gainers. Although none of the variables exerted individually an overwhelmingly strong influence on overfeeding-induced changes, baseline FFM, maximal oxygen uptake, muscle oxidative capacity, androgens, and leptin levels were the most consistent significant biomarkers of the responsiveness to chronic overfeeding.
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影响因子：
158.5
作者：
BOUCHARD, C;TREMBLAY, A;FOURNIER, G
通讯作者：
FOURNIER, G
影响因子：
8.2
作者：
BERNE, C;FAGIUS, J;HJEMDAHL, P
通讯作者：
HJEMDAHL, P
DOI：
10.1016/j.jsbmb.2007.09.001
发表时间：
2008-02-01
影响因子：
4.1
作者：
Blouin, Karine;Boivin, Ariane;Tchernof, Andre
通讯作者：
Tchernof, Andre
影响因子：
3.6
作者：
FORBES, GB;BROWN, MR;LIPINSKI, BA
通讯作者：
LIPINSKI, BA
影响因子：
6.5
作者：
Gerrits, Martin F.;Ghosh, Sujoy;Harper, Mary-Ellen
通讯作者：
Harper, Mary-Ellen