Quantitative analysis of the bilateral brainstem projections from the whisker and forepaw regions in rat primary motor cortex.
Quantitative analysis of the bilateral brainstem projections from the whisker and forepaw regions in rat primary motor cortex.
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DOI：
10.1002/cne.22477
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发表时间：
2010-11-15
影响因子：
2.5
通讯作者：
Beauchemin, Kyle J.
中科院分区：
文献类型：
--
作者：
Alloway, Kevin D.;Smith, Jared B.;Beauchemin, Kyle J.
关键词：
大鼠初级运动（MI）皮层的胡须区域投射到多个脑干区域，但这些投射的相对强度尚未表征。我们最近量化了对前脑双侧目标的 MI 预测，本研究通过量化对脑干双侧目标的 MI 预测来扩展这些发现。我们发现 MI 中的胡须和前爪区域对基底脑桥和上丘的投射最为强烈。虽然 MI 前爪区域主要投射到同侧基底脑桥，但 MI 胡须区域与对侧的连接明显更多。这种双边差异表明，来自 MI 胡须区域的皮质桥脑投射可能在协调双边胡须运动中发挥作用。 MI 中的顺行示踪剂注射没有显示任何对面核的直接投射，但面核中的逆行示踪剂注射显示了 MI 皮质中的一些标记神经元。然而，MI 中逆行标记神经元的数量与上丘和其他脑干区域中大量标记神经元的数量相形见绌。总之，我们的顺行和逆行追踪结果表明，上丘提供了将信息从 MI 传输到面核的最有效途径。
The whisker region in rat primary motor (MI) cortex projects to several brainstem regions, but the relative strength of these projections has not been characterized. We recently quantified the MI projections to bilateral targets in the forebrain, and the present study extends those findings by quantifying the MI projections to bilateral targets in the brainstem. We found that both the whisker and forepaw regions in MI project most strongly to the basal pons and superior colliculus. While the MI forepaw region projects mainly to the ipsilateral basilar pons, the MI whisker region has significantly more connections with the contralateral side. This bilateral difference suggests that corticopontine projections from the MI whisker region may have a role in coordinating bilateral whisker movements. Anterograde tracer injections in MI did not reveal any direct projections to the facial nucleus, but retrograde tracer injections in the facial nucleus revealed some labeled neurons in MI cortex. The number of retrogradely-labeled neurons in MI, however, was dwarfed by a much larger number of labeled neurons in the superior colliculus and other brainstem regions. Together, our anterograde and retrograde tracing results indicate that the superior colliculus provides the most effective route for transmitting information from MI to the facial nucleus.
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