Fraction n-Butanol of Radix Notoginseng Protects PC12 Cells from Aβ(25-35)-Induced Cytotoxicity and Alleviates Cognitive Deficits in SAMP8 Mice by Attenuating Oxidative Stress and Aβ Accumulation.
Fraction n-Butanol of Radix Notoginseng Protects PC12 Cells from Aβ(25-35)-Induced Cytotoxicity and Alleviates Cognitive Deficits in SAMP8 Mice by Attenuating Oxidative Stress and Aβ Accumulation.
复制标题
三七正丁醇成分可保护 PC12 细胞免受 Aβ(25-35) 诱导的细胞毒性，并通过减轻氧化应激和 Aβ 积累来减轻 SAMP8 小鼠的认知缺陷
DOI：
10.1155/2017/8469754
复制
发表时间：
2017
期刊：
影响因子：
--
通讯作者：
Zhong ZG
中科院分区：
文献类型：
--
作者：
Huang JL;Feng YQ;Bai LR;Qin MC;Xu ZH;Liu ZR;Chen WB;Wu DP;Zhong ZG
中医药治疗阿尔茨海默病已有数千年的历史，疗效更好，副作用更少。因此，从中药中开发有效的潜在候选药物将被认为是治疗AD的关键和有效的治疗方法。本研究旨在观察中药葛根正丁醇部位（NB）对Aβ25-35诱导的PC 12细胞的神经保护作用，探讨其对空间学习记忆能力的影响，以及对抗氧化酶、Aβ生成、APP和BACE 1表达的影响。结果表明，NB组分对Aβ25-35诱导的PC 12细胞凋亡具有明显的保护和挽救作用。NB组分可改善SAMP 8小鼠的空间学习记忆障碍，并通过抑制SAMP 8小鼠脑内APP和BACE 1的表达，减轻氧化应激，减少Aβ的产生。单次给药急性毒性试验结果表明，NB组分对小鼠有轻度毒性。NB组分对AD的显著作用和体内低毒性表明NB组分可能是目前AD治疗的有用替代品。
Chinese medicine has been used for Alzheimer's disease (AD) treatment for thousands of years with more effective and fewer side effects. Therefore, developing effective potential candidates from Chinese medicine against AD would be considered as critical and efficient therapy for AD treatment. This study was designed to evaluate the neuronal protective effect of fraction n-butanol (NB) of Radix Notoginseng on Aβ25–35-induced PC12 cells, explore the effect of the tested fraction on spatial learning and memory, and characterize the impacts of fraction NB on antioxidant enzymes, Aβ production, and APP and BACE1 expressions. The results revealed that fraction NB could promote proliferation of PC12 cells and protect and rescue PC12 cells from Aβ25–35-induced cell death. Moreover, fraction NB could improve spatial learning and memory impairments of senescence-accelerated prone8 (SAMP8) mice and attenuate oxidative stress and reduce the production of Aβ by inhibiting the expressions of APP and BACE1 in the brains of SAMP8 mice. The result of single dose acute toxicity assay showed that fraction NB had a mild toxicity in vivo. The pronounced actions against AD and in vivo low toxicity of fraction NB suggest that fraction NB may be a useful alternative to the current AD treatment.
登录
查看更多内容
影响因子：
6.1
作者：
Liu J;He J;Huang L;Dou L;Wu S;Yuan Q
通讯作者：
Yuan Q
Cestrum nocturnum 花提取物通过诱导 DNA 损伤和抑制拓扑异构酶 II 活性来减弱恶性肿瘤细胞的增殖并诱导细胞凋亡
DOI：
10.1155/2017/1456786
发表时间：
2017
期刊：
Evidence-based complementary and alternative medicine : eCAM
影响因子：
--
作者：
Wu DP;Lin TY;Lv JY;Chen WY;Bai LR;Zhou Y;Huang JL;Zhong ZG
通讯作者：
Zhong ZG
影响因子：
7.2
作者：
Wang, Chong-Zhi;Xie, Jing-Tian;Fishbein, Anna;Aung, Han H.;He, Hui;Mehendale, Sangeeta R.;He, Tong-Chuan;Du, Wei;Yuan, Chun-Su
通讯作者：
Yuan, Chun-Su
针对γ-/β-分泌酶相互作用可减少β-淀粉样蛋白的生成并改善阿尔茨海默病相关的发病机制。
影响因子：
33.5
作者：
Cui J;Wang X;Li X;Wang X;Zhang C;Li W;Zhang Y;Gu H;Xie X;Nan F;Zhao J;Pei G
通讯作者：
Pei G
影响因子：
6.3
作者：
Chang, Sun-Hwa;Choi, Youngnim;Kim, Jung-Keun
通讯作者：
Kim, Jung-Keun