Effects of autonomic nerve stimulation on colorectal motility in rats.
Effects of autonomic nerve stimulation on colorectal motility in rats.
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DOI：
10.1111/j.1365-2982.2009.01461.x
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发表时间：
2010-06
影响因子：
3.5
通讯作者：
Takahashi T
中科院分区：
文献类型：
--
作者：
Tong WD;Ridolfi TJ;Kosinski L;Ludwig K;Takahashi T
结肠和直肠的几种疾病过程，包括便秘和失禁，与自主神经系统异常有关。然而，对结肠和直肠的自主神经支配尚未完全了解。本研究旨在探讨刺激迷走神经、盆神经（PN）和腹下神经（HGN）对大鼠结肠运动的影响。将四个应变传感器植入近端结肠、中段结肠、远端结肠和直肠，记录大鼠环行肌收缩。电刺激颈迷走神经、PN和HGN的传出远端。在刺激前和刺激期间评价运动指数（MI）。电刺激（5-20 Hz）颈部迷走神经引起显着的收缩中结肠和远端结肠，而不太明显的收缩，观察到在近端结肠。PN刺激引起直肠以及中结肠和远端结肠的显著收缩。阿托品治疗几乎完全消除迷走神经和PN刺激引起的收缩。刺激HGN引起直肠、中结肠和远端结肠的松弛。对HGN刺激的舒张反应被普萘洛尔消除。迷走神经支配延伸到远端结肠，而PN在直肠的分布中具有通过结肠中段的投射。这表明在左结肠有双重副交感神经支配。副交感神经纤维通过毒蕈碱受体调节结直肠收缩。HGN主要通过β-肾上腺素受体调节结肠直肠舒张。
Several disease processes of the colon and rectum, including constipation and incontinence, have been associated with abnormalities of the autonomic nervous system. However, the autonomic innervation to the colon and rectum are not fully understood. The aims of this study were to investigate the effect of stimulation of vagus nerves, pelvic nerves (PN) and hypogastric nerves (HGN) on colorectal motility in rats. Four strain gauge transducers were implanted on the proximal colon, mid colon, distal colon and rectum to record circular muscle contractions in rats. Electrical stimulation was administered to the efferent distal ends of the cervical vagus nerve, PN and HGN. Motility index (MI) was evaluated before and during stimulation. Electrical stimulation (5–20 Hz) of the cervical vagus elicited significant contractions in the mid colon and distal colon, whereas less pronounced contractions were observed in the proximal colon. PN stimulation elicited significant contractions in the rectum as well as the mid colon and distal colon. Atropine treatment almost completely abolished the contractions induced by vagus nerve and PN stimulation. HGN stimulation caused relaxations in the rectum, mid colon and distal colon. The relaxations in response to HGN stimulation were abolished by propranolol. Vagal innervation extends to the distal colon, while the PN has projections in the distribution of the rectum through the mid colon. This suggests a pattern of dual parasympathetic innervation in the left colon. Parasympathetic fibers regulate colorectal contractions via muscarinic receptors. The HGN mainly regulates colorectal relaxations via beta-adrenoceptors.
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影响因子：
5.5
作者：
BENNETT, MR
通讯作者：
BENNETT, MR
影响因子：
3.9
作者：
Hirabayashi, T;Matsufuji, H;Kitajima, M
通讯作者：
Kitajima, M
影响因子：
5.5
作者：
GARRETT, JR;HOWARD, ER;JONES, W
通讯作者：
JONES, W
DOI：
10.1111/j.1748-1716.1984.tb07462.x
发表时间：
1984-01-01
期刊：
ACTA PHYSIOLOGICA SCANDINAVICA
影响因子：
--
作者：
HEDLUND, H;FASTH, S;HULTEN, L
通讯作者：
HULTEN, L
影响因子：
3.1
作者：
Ishikawa, M;Mibu, R;Tanaka, M
通讯作者：
Tanaka, M