Linking irritability and functional brain networks: A transdiagnostic case for expanding consideration of development and environment in RDoC.
Linking irritability and functional brain networks: A transdiagnostic case for expanding consideration of development and environment in RDoC.
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DOI：
10.1016/j.neubiorev.2021.07.022
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发表时间：
2021-10
影响因子：
8.2
通讯作者：
Norton ES
中科院分区：
文献类型：
--
作者：
Nielsen AN;Wakschlag LS;Norton ES
国家精神卫生研究所的研究领域标准（RDoC）框架促进了精神病理学的维度和transdiagnosis操作化，但考虑到精神健康问题的神经发育基础需要更深入的检查。易怒是一种具有情绪和行为因素的愤怒情绪的倾向性，在生命的早期是维度的、可转化的和可观察的，是一个有希望的识别早期神经指标或精神病理学危险因素的目标。在这里，我们研究了从学龄前到成年期与易怒相关的功能性大脑网络，并讨论了发育和早期经历如何影响这些神经基质。功能性连接与功能磁共振成像测量不同，根据易怒，并表示参与情绪生成，情绪感知，注意力，内化和认知控制的几个功能网络的非典型协调。我们制定了一个议程，以提高我们的理解和检测的非典型大脑：行为模式，通过两个功能网络和易怒的表征，以及考虑和操作化的发展和早期生活环境对这条途径的影响。
The National Institute of Mental Health Research Domain Criteria (RDoC) framework promotes the dimensional and transdiagnostic operationalization of psychopathology, but consideration of the neurodevelopmental foundations of mental health problems requires deeper examination. Irritability, the dispositional tendency to angry emotion that has both mood and behavioral elements, is dimensional, transdiagnostic, and observable early in life—a promising target for the identification of early neural indicators or risk factors for psychopathology. Here, we examine functional brain networks linked to irritability from preschool to adulthood and discuss how development and early experience may influence these neural substrates. Functional connectivity measured with fMRI varies according to irritability and indicates the atypical coordination of several functional networks involved in emotion generation, emotion perception, attention, internalization, and cognitive control. We lay out an agenda to improve our understanding and detection of atypical brain:behavior patterns through advances in the characterization of both functional networks and irritability as well as the consideration and operationalization of developmental and early life environmental influences on this pathway.
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DOI：
10.1073/pnas.0504136102
发表时间：
2005-07-05
影响因子：
11.1
作者：
Fox, MD;Snyder, AZ;Raichle, ME
通讯作者：
Raichle, ME
影响因子：
3.6
作者：
De Los Reyes, Andres;Henry, David B.;Wakschlag, Lauren S.
通讯作者：
Wakschlag, Lauren S.
影响因子：
16.2
作者：
Cui, Zaixu;Li, Hongming;Satterthwaite, Theodore D.
通讯作者：
Satterthwaite, Theodore D.
影响因子：
5.7
作者：
Finn ES;Scheinost D;Finn DM;Shen X;Papademetris X;Constable RT
通讯作者：
Constable RT
影响因子：
3.4
作者：
Bennett, Randi H.;Somandepalli, Krishna;Di Martino, Adriana
通讯作者：
Di Martino, Adriana