Low lean mass with obesity in older adults with hypertension: prevalence and association with mortality rate.
Low lean mass with obesity in older adults with hypertension: prevalence and association with mortality rate.
复制标题
老年高血压患者低瘦体重伴肥胖：患病率及其与死亡率的关系。
DOI：
10.1186/s12877-023-04326-x
复制
发表时间：
2023-10-03
期刊：
影响因子：
4.1
通讯作者：
Gao, Rongrong
中科院分区：
文献类型：
--
作者：
Qu, Qiang;Guo, Qixin;Sun, Jinyu;Lu, Xinyi;Cheang, Iokfai;Zhu, Xu;Yao, Wenming;Li, Xinli;Zhang, Haifeng;Zhou, Yanli;Liao, Shengen;Gao, Rongrong
关键词：
The influence of sarcopenic obesity (SO) on overall survival in older adults with hypertension has not been addressed. The aim of this study was to investigate the prevalence and mortality predictive value of various body composition phenotypes, focusing mainly on SO, in older adults with hypertension. We included 1105 hypertensive patients aged ≥ 60 years from the National Health and Nutrition Examination Survey 1999–2004. Sarcopenia was broadly defined based on low lean mass (LLM; as measured by dual-energy X-ray absorptiometry), and was defined using appendicular lean mass (ALM) divided by height squared (ALM/height2), weight (ALM/weight), and body mass index (BMI; ALM/BMI), respectively. Obesity was defined as BMI ≥ 30 kg/m2, body fat percentage ≥ 30/42%, or waist circumference ≥ 102/88 cm. The prevalence of LLM with obesity was estimated according to each ALM index (ALMI). Multivariable Cox regression analysis and sensitivity analysis were used to examine the association between various body composition phenotypes and all-cause mortality. In older adults with hypertension, the prevalence of LLM with obesity by the ALM/height2 index (9.8%) was lower relative to the ALM/weight (11.7%) and ALM/BMI indexes (19.6%). After a median follow-up of 15.4 years, 642 deaths occurred. In the fully adjusted models, LLM with obesity was significantly associated with a higher risk of all-cause mortality (hazard ratio [HR] 1.69, 95% confidence interval [CI] 1.14–2.49, P = 0.008; HR 1.48, 95% CI 1.04–2.10, P = 0.028; HR 1.30, 95% CI 1.02–1.66, P = 0.037; respectively) compared with the normal body phenotype, with no statistical differences found in individuals with LLM or obesity alone. Sensitivity analysis confirmed the robustness of the results. The prevalence of LLM with obesity markedly differed in older adults with hypertension according to the 3 different ALMIs, varying from 9.8%, 11.7%, to 19.6%. Patients with both LLM and obesity had a higher risk of all-cause mortality. Further large, prospective, cohort studies are warranted to validate these findings and uncover underlying mechanisms. The online version contains supplementary material available at 10.1186/s12877-023-04326-x.
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DOI：
10.1002/jcsm.12754
发表时间：
2021-10
期刊：
Journal of cachexia, sarcopenia and muscle
影响因子：
--
作者：
Chun HS;Kim MN;Lee JS;Lee HW;Kim BK;Park JY;Kim DY;Ahn SH;Kim SU
通讯作者：
Kim SU
影响因子：
6.3
作者：
Gao, Qianqian;Mei, Fan;Ma, Bin
通讯作者：
Ma, Bin
影响因子：
2.5
作者：
Cauley, Jane A.
通讯作者：
Cauley, Jane A.
影响因子：
4.1
作者：
Zhang X;Zhang W;Wang C;Tao W;Dou Q;Yang Y
通讯作者：
Yang Y
DOI：
10.1093/gerona/glt026
发表时间：
2014-01-01
影响因子：
5.1
作者：
Canning, Karissa L.;Brown, Ruth E.;Kuk, Jennifer L.
通讯作者：
Kuk, Jennifer L.