Diminished omega-3 fatty acids are associated with carotid plaques from neurologically symptomatic patients: Implications for carotid interventions.
Diminished omega-3 fatty acids are associated with carotid plaques from neurologically symptomatic patients: Implications for carotid interventions.
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DOI：
10.1016/j.vph.2009.08.003
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发表时间：
2009-11
影响因子：
4
通讯作者：
Dardik, Alan
中科院分区：
文献类型：
--
作者：
Bazan, Hernan A.;Lu, Yan;Thoppil, Deepu;Fitzgerald, Tamara N.;Hong, Song;Dardik, Alan
ω-3脂肪酸，二十碳五烯酸（EPA）和二十二碳六烯酸（DHA），是鱼油中普遍存在的，它们的心脏保护作用被认为是由抗炎机制介导的。本研究的目的是确定ω-3脂肪酸是否与神经系统症状患者的颈动脉斑块相关。从41名患者中获得斑块（平均年龄62 [44 - 84]; 24名无症状，17名有症状）。用质谱法评估斑块内脂质。与无症状患者相比，在神经系统症状患者的颈动脉斑块中发现了显著减少的ω-3脂肪酸DHA（545.8 ± 98 ng/g vs. 270.7 ± 19.6 ng/g，p=0.0096）和EPA（385.9 ± 68 ng/g vs. 216.4 ± 17.6 ng/g，p=0.0189）。然而，在ω-6脂肪酸花生四烯酸的水平上没有发现差异（p=0.2003）。免疫组织化学和ELISA分析（CD 68+细胞，0.461 ± 0.04 vs. 0.312 ± 0.03，p=0.003）表明，与无症状患者相比，神经系统症状患者斑块中的炎性浸润增加。来自神经系统症状患者的颈动脉斑块是炎性的，并且具有降低的斑块内ω-3脂肪酸水平。未来的试验将确定增加ω-3脂肪酸掺入颈动脉斑块的干预措施是否能预防中风并提高颈动脉干预措施的安全性。
The omega-3 fatty acids, eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), are prevalent in fish oil and their cardioprotective effects are thought to be mediated by anti-inflammatory mechanisms. The aim of this study is to determine whether omega-3 fatty acids are associated with carotid plaques from neurologically symptomatic patients. Plaques were obtained from 41 patients (mean age 62 [44 – 84]; 24-asymptomatic, 17-symptomatic). Intra-plaque lipids were assessed with mass spectrometry. Compared to asymptomatic patients, significantly diminished omega-3 fatty acids DHA (545.8 ± 98 ng/g vs. 270.7 ± 19.6 ng/g, p=0.0096) and EPA (385.9 ± 68 ng/g vs. 216.4 ± 17.6 ng/g, p=0.0189) were found in carotid plaques from neurologically symptomatic patients. However, no differences were found in the levels of the omega-6 fatty acid arachidonic acid (p=0.2003). Immunohistochemistry and ELISA analysis (CD68+ cells, 0.461 ± 0.04 vs. 0.312 ± 0.03, p=0.003) demonstrated an increased inflammatory infiltrate in plaques from neurologically symptomatic, compared to asymptomatic, patients. Carotid plaques from neurologically symptomatic patients are inflammatory and have decreased intra-plaque levels of omega-3 fatty acids. Future trials will determine whether interventions that increase omega-3 fatty acid incorporation into carotid plaques prevent stroke and improve the safety of carotid interventions.
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