Transcriptomic and Genetic Profiling of HIV-Associated Neurocognitive Disorders.
Transcriptomic and Genetic Profiling of HIV-Associated Neurocognitive Disorders.
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DOI：
10.3389/fmolb.2021.721954
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发表时间：
2021
影响因子：
5
通讯作者：
Kaul M
中科院分区：
文献类型：
--
作者：
Ojeda-Juárez D;Kaul M
在艾滋病毒大流行的早期，很明显，艾滋病毒感染者（PLWH）会出现广泛的神经和神经认知并发症。即使在引入联合抗逆转录病毒治疗（cART），大大提高了PLWH的生存率，与某种形式的艾滋病毒相关的神经认知障碍（HAND）的总人数似乎保持不变，虽然痴呆症的发病率下降，并出现了关于最温和形式的HAND的发病率和诊断的问题。为了更好地了解这种复杂的疾病，已经在尸检样品以及非人灵长类动物和小动物啮齿动物模型中进行了几次转录组学分析。然而，HIV领域的遗传学研究主要集中在免疫系统的遗传组成上。关于HAND的遗传基础，我们知道的要少得多。在这里，我们提供了一个摘要的转录组和表观遗传变化的手，以及一些潜在的遗传基础，已链接到手，并讨论未来的方向与障碍，以克服和角度，仍有待探索。
Early in the HIV pandemic, it became evident that people living with HIV (PLWH) develop a wide range of neurological and neurocognitive complications. Even after the introduction of combination antiretroviral therapy (cART), which dramatically improved survival of PLWH, the overall number of people living with some form of HIV-associated neurocognitive disorders (HAND) seemed to remain unchanged, although the incidence of dementia declined and questions about the incidence and diagnosis of the mildest form of HAND arose. To better understand this complex disease, several transcriptomic analyses have been conducted in autopsy samples, as well as in non-human primates and small animal rodent models. However, genetic studies in the HIV field have mostly focused on the genetic makeup of the immune system. Much less is known about the genetic underpinnings of HAND. Here, we provide a summary of reported transcriptomic and epigenetic changes in HAND, as well as some of the potential genetic underpinnings that have been linked to HAND, and discuss future directions with hurdles to overcome and angles that remain to be explored.
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Apoε4 等位基因、HIV 感染、年龄、神经心理学结果或死亡之间没有关联。
影响因子：
3.2
作者：
Becker JT;Martinson JJ;Penugonda S;Kingsley L;Molsberry S;Reynolds S;Aronow A;Goodkin K;Levine A;Martin E;Miller EN;Munro CA;Ragin A;Sacktor N
通讯作者：
Sacktor N
DOI：
10.1007/s11481-010-9254-3
发表时间：
2011-09
期刊：
Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology
影响因子：
--
作者：
Andres MA;Feger U;Nath A;Munsaka S;Jiang CS;Chang L
通讯作者：
Chang L
DOI：
10.1093/database/bav074
发表时间：
2015
期刊：
Database : the journal of biological databases and curation
影响因子：
--
作者：
Cserhati MF;Pandey S;Beaudoin JJ;Baccaglini L;Guda C;Fox HS
通讯作者：
Fox HS
影响因子：
3.8
作者：
Asahchop, Eugene L.;Akinwumi, Segun M.;Power, Christopher
通讯作者：
Power, Christopher
影响因子：
56.9
作者：
BARRESINOUSSI, F;CHERMANN, JC;MONTAGNIER, L
通讯作者：
MONTAGNIER, L