Cardiorespiratory fitness attenuates age-associated aggregation of white matter hyperintensities in an at-risk cohort.
Cardiorespiratory fitness attenuates age-associated aggregation of white matter hyperintensities in an at-risk cohort.
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DOI：
10.1186/s13195-018-0429-0
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发表时间：
2018-09-24
期刊：
影响因子：
--
通讯作者：
Okonkwo OC
中科院分区：
文献类型：
--
作者：
Vesperman CJ;Pozorski V;Dougherty RJ;Law LL;Boots E;Oh JM;Gallagher CL;Carlsson CM;Rowley HA;Ma Y;Bendlin BB;Asthana S;Sager MA;Hermann BP;Johnson SC;Cook DB;Okonkwo OC
Age is the cardinal risk factor for Alzheimer’s disease (AD), and white matter hyperintensities (WMH), which are more prevalent with increasing age, may contribute to AD. Higher cardiorespiratory fitness (CRF) has been shown to be associated with cognitive health and decreased burden of AD-related brain alterations in older adults. Accordingly, the aim of this study was to determine whether CRF attenuates age-related accumulation of WMH in middle-aged adults at risk for AD. One hundred and seven cognitively unimpaired, late-middle-aged adults from the Wisconsin Registry for Alzheimer’s Prevention underwent 3 T magnetic resonance imaging and performed graded maximal treadmill exercise testing from which we calculated the oxygen uptake efficiency slope (OUES) as our measure of CRF. Total WMH were quantified using the Lesion Segmentation Tool and scaled to intracranial volume. Linear regression adjusted for APOE4 carriage, family history, body mass index, systolic blood pressure, and sex was used to examine relationships between age, WMH, and CRF. As expected, there was a significant association between age and WMH (p < .001). Importantly, there was a significant interaction between age and OUES on WMH (p = .015). Simple main effects analyses revealed that the effect of age on WMH remained significant in the Low OUES group (p < .001) but not in the High OUES group (p = .540), indicating that higher CRF attenuates the deleterious age association with WMH. Higher CRF tempers the adverse effect of age on WMH. This suggests a potential pathway through which increased aerobic fitness facilitates healthy brain aging, especially among individuals at risk for AD.
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DOI：
10.1136/bmj.c3666
发表时间：
2010-07-26
期刊：
BMJ (Clinical research ed.)
影响因子：
--
作者：
Debette S;Markus HS
通讯作者：
Markus HS
影响因子：
2.3
作者：
Brickman, Adam M.;Zahra, Amir;Muraskin, Jordan;Steffener, Jason;Holland, Christopher M.;Habeck, Christian;Borogovac, Ajna;Ramos, Marco A.;Brown, Truman R.;Asllani, Iris;Stern, Yaakov
通讯作者：
Stern, Yaakov
影响因子：
3.7
作者：
Burzynska, Agnieszka Zofia;Chaddock-Heyman, Laura;Kramer, Arthur F.
通讯作者：
Kramer, Arthur F.
影响因子：
--
作者：
Brickman, Adam M.;Provenzano, Frank A.;Muraskin, Jordan;Manly, Jennifer J.;Blum, Sonja;Apa, Zoltan;Stern, Yaakov;Brown, Truman R.;Luchsinger, Jose A.;Mayeux, Richard
通讯作者：
Mayeux, Richard
影响因子：
5.7
作者：
Keihaninejad, Shiva;Heckemann, Rolf A.;Fagiolo, Gianlorenzo;Symms, Mark R.;Hajnal, Joseph V.;Hammers, Alexander
通讯作者：
Hammers, Alexander