PKC-mediated GABAergic enhancement of dopaminergic responses: implication for short-term potentiation at a dual-transmitter synapse.
PKC-mediated GABAergic enhancement of dopaminergic responses: implication for short-term potentiation at a dual-transmitter synapse.
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PKC 介导的 GABA 能增强多巴胺能反应：双递质突触短期增强的意义。
DOI：
10.1152/jn.00794.2013
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发表时间：
2014
影响因子：
2.5
通讯作者：
Weiss,KlaudiuszR
中科院分区：
文献类型：
--
作者：
Svensson,Erik;Proekt,Alex;Jing,Jian;Weiss,KlaudiuszR
递质介导的同突触增强通常由介导兴奋性突触后电位（epsp）的同一递质实现，例如谷氨酸。然而，当突触前神经元包含一个以上的递质时，增强原则上可以由一个不同于引发epsp的递质来实现。神经元B20同时含有多巴胺和GABA。虽然只有多巴胺作为b20 - b8突触的快速兴奋传递素，但GABA增加了这些多巴胺能epsp的大小。我们现在提供的证据表明，反复刺激B20可以通过突触后机制增强B20在B8中诱发的多巴胺能epsp，并且该突触的短期增强对于建立和维持分泌网络状态至关重要。我们发现GABA可以在突触后增加多巴胺电流，这种电流是由多巴胺直接作用于B8引起的，多巴胺作用于5- ht3样受体。这种增强作用由gabab样受体介导，分别作为gabab受体激动剂和拮抗剂，模拟和阻断GABA的增强作用。GABA的突触后作用依赖于G蛋白介导的PKC激活。我们的研究结果表明，突触后共递质介导的增强作用可能有助于维持进食网络的消化状态，更一般地说，可能参与调节复杂行为的网络的可塑性。
Transmitter-mediated homosynaptic potentiation is generally implemented by the same transmitter that mediates the excitatory postsynaptic potentials (EPSPs), e.g., glutamate. When a presynaptic neuron contains more than one transmitter, however, potentiation can in principle be implemented by a transmitter different from that which elicits the EPSPs. Neuron B20 inAplysiacontains both dopamine and GABA. Although only dopamine acts as the fast excitatory transmitter at the B20-to-B8 synapse, GABA increases the size of these dopaminergic EPSPs. We now provide evidence that repeated stimulation of B20 potentiates B20-evoked dopaminergic EPSPs in B8 apparently via a postsynaptic mechanism, and short-term potentiation of this synapse is critical for the establishment and maintenance of an egestive network state. We show that GABA can act postsynaptically to increase dopamine currents that are elicited by direct applications of dopamine to B8 and that dopamine is acting on a 5-HT3-like receptor. This potentiation is mediated by GABAB-like receptors as GABAB-receptor agonists and antagonists, respectively, mimicked and blocked the potentiating actions of GABA. The postsynaptic actions of GABA rely on a G protein-mediated activation of PKC. Our results suggest that the postsynaptic action of cotransmitter-mediated potentiation may contribute to the maintenance of the egestive state ofAplysiafeeding network and, in more general terms, may participate in the plasticity of networks that mediate complex behaviors.
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影响因子：
3.8
作者：
Celina Rodicio, M.;Villar-Cervino, Verona;Anadon, Ramon
通讯作者：
Anadon, Ramon
海兔感觉神经元中蛋白激酶 C 激活引起的兴奋性的长期变化。
DOI：
10.1152/jn.1998.79.3.1210
发表时间：
1998
期刊：
Journal of neurophysiology.
影响因子：
--
作者：
Manseau,F;Sossin,WS;Castellucci,VF
通讯作者：
Castellucci,VF
影响因子：
2.9
作者：
T. Teyke;S. Rosen;K. R. Weiss;I. Kupfermann
通讯作者：
T. Teyke;S. Rosen;K. R. Weiss;I. Kupfermann
影响因子：
2.5
作者：
Due, MR;Jing, J;Weiss, KR
通讯作者：
Weiss, KR
影响因子：
2.5
作者：
Maher, Brady J.;Westbrook, Gary L.
通讯作者：
Westbrook, Gary L.