Emergence of infectious malignant thrombocytopenia in Japanese macaques (Macaca fuscata) by SRV-4 after transmission to a novel host.
Emergence of infectious malignant thrombocytopenia in Japanese macaques (Macaca fuscata) by SRV-4 after transmission to a novel host.
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DOI：
10.1038/srep08850
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发表时间：
2015-03-06
影响因子：
4.6
通讯作者：
Hirai H
中科院分区：
文献类型：
--
作者：
Okamoto M;Miyazawa T;Morikawa S;Ono F;Nakamura S;Sato E;Yoshida T;Yoshikawa R;Sakai K;Mizutani T;Nagata N;Takano J;Okabayashi S;Hamano M;Fujimoto K;Nakaya T;Iida T;Horii T;Miyabe-Nishiwaki T;Watanabe A;Kaneko A;Saito A;Matsui A;Hayakawa T;Suzuki J;Akari H;Matsuzawa T;Hirai H
我们在京都大学灵长类动物研究所饲养的日本猕猴中发现了一种由严重血小板减少引起的致死性出血综合征。广泛的调查表明，猴逆转录病毒4型（SRV-4）是该病的病原体。先前仅从食蟹猴中分离到SRV-4，食蟹猴通常无症状。我们认为，SRV-4跨越了食蟹猴和日本猕猴之间的所谓物种屏障，导致后者出现极严重的急性症状。跨越物种屏障的感染性病原体偶尔会增强毒力，这在原始宿主中没有观察到。在这种情况下，新宿主通常与原始宿主有远亲关系。然而，日本猕猴与食蟹猴密切相关，甚至可以在有机会时杂交。日本猕猴中这种新型病原体的致命爆发凸显了我们需要修改关于跨物种障碍的毒力预期。
We discovered a lethal hemorrhagic syndrome arising from severe thrombocytopenia in Japanese macaques kept at the Primate Research Institute, Kyoto University. Extensive investigation identified that simian retrovirus type 4 (SRV-4) was the causative agent of the disease. SRV-4 had previously been isolated only from cynomolgus macaques in which it is usually asymptomatic. We consider that the SRV-4 crossed the so-called species barrier between cynomolgus and Japanese macaques, leading to extremely severe acute symptoms in the latter. Infectious agents that cross the species barrier occasionally amplify in virulence, which is not observed in the original hosts. In such cases, the new hosts are usually distantly related to the original hosts. However, Japanese macaques are closely related to cynomolgus macaques, and can even hybridize when given the opportunity. This lethal outbreak of a novel pathogen in Japanese macaques highlights the need to modify our expectations about virulence with regards crossing species barriers.
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影响因子：
1.6
作者：
Hara, Masayuki;Kikuchi, Toshihiko;Mukai, Ryozaburo
通讯作者：
Mukai, Ryozaburo
影响因子：
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Bellau-Pujol S;Vabret A;Legrand L;Dina J;Gouarin S;Petitjean-Lecherbonnier J;Pozzetto B;Ginevra C;Freymuth F
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