Reliability and validity of a MR-based volumetric analysis of the intrinsic foot muscles.

Reliability and validity of a MR-based volumetric analysis of the intrinsic foot muscles.
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DOI:
10.1002/jmri.24069
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发表时间:
2013-11
影响因子:
4.4
通讯作者:
Mueller, Michael J.
Mueller, Michael J.
中科院分区:
医学2区
文献类型:
--
作者:
Cheuy, Victor A.;Commean, Paul K.;Hastings, Mary K.;Mueller, Michael J.

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描述一个半自动程序,该程序将使用磁共振(MR)成像分割足部皮下脂肪、肌肉和脂肪组织,确定该程序在评分者之间和内部的可靠性,并使用MR模体确定该程序的有效性。19名患有和不患有糖尿病和周围神经病变的受试者均获得了磁共振图像。两名评分员在两个不同的时间对前足、中足和后足的单个MR切片进行分割并测量体积。确定了评分者内和评分者间的相关系数。该程序测量了已知体积的肌肉和脂肪MR模型。多数ICC信度系数均在0.950以上。比较MR估计和已知体积的有效性估计导致所有模体的R2值都在0.970以上。所有模体的均方根误差均小于5%。足部的皮下脂肪、瘦肉和脂肪组织体积可以可靠而有效地量化。该程序可用于未来研究这些足部结构与重要病理中的功能的关系,包括神经性足部或其他肌肉骨骼问题。
To describe a semi-automated program that will segment subcutaneous fat, muscle, and adipose tissue in the foot using magnetic resonance (MR) imaging, determine the reliability of the program between and within raters, and determine the validity of the program using MR phantoms. MR images were acquired from 19 subjects with and without diabetes and peripheral neuropathy. Two raters segmented and measured volumes from single MR slices at the forefoot, midfoot, and hindfoot at two different times. Intra and inter-rater correlation coefficients were determined. Muscle and fat MR phantoms of known volumes were measured by the program. Most ICC reliability values were over 0.950. Validity estimates comparing MR estimates and known volumes resulted in r2 values above 0.970 for all phantoms. The root mean square error was less than 5% for all phantoms. Subcutaneous fat, lean muscle, and adipose tissue volumes in the foot can be quantified in a reliable and valid way. This program can be applied in future studies investigating the relationship of these foot structures to functions in important pathologies including the neuropathic foot or other musculoskeletal problems.
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