Non-human Primate Determinants of Natural Killer Cells in Tissues at Steady-State and During Simian Immunodeficiency Virus Infection.
Non-human Primate Determinants of Natural Killer Cells in Tissues at Steady-State and During Simian Immunodeficiency Virus Infection.
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DOI：
10.3389/fimmu.2020.02134
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发表时间：
2020
影响因子：
7.3
通讯作者：
Müller-Trutwin M
中科院分区：
文献类型：
--
作者：
Huot N;Rascle P;Petitdemange C;Contreras V;Palgen JL;Stahl-Hennig C;Le Grand R;Beignon AS;Jacquelin B;Müller-Trutwin M
自然杀伤（NK）细胞在对病毒和肿瘤的免疫中发挥重要作用。它们的功能由遗传决定，但也受环境因素的调节。这些细胞的分布和功能调节取决于组织。淋巴组织中的NK细胞行为迄今尚未得到充分研究。非人灵长类动物（NHP）模型对于开发针对人类疾病的疗法和疫苗至关重要，并且获得NHP组织可以深入了解NK细胞的空间调节。在这里，我们研究了来自NHP物种的NK细胞的组织特异性参数，即，食蟹猴（Macaca fascicularis）、非洲绿色猴（Chlorocebus sabaeus）、恒河猴（Macaca mulatta）和狒狒（Papio anubis）。通过对来自次级淋巴器官、肠粘膜、肝脏和血液的NK细胞进行全面的多维分析，我们确定了NK细胞频率、表型和潜在活性的组织和物种特异性模式。此外，我们还确定了猴免疫缺陷病毒感染过程中NK细胞的组织特异性特征。总之，我们的研究结果提供了一个全面的解剖分析的NK细胞在不同组织的灵长类动物在稳态和病毒感染。
Natural killer (NK) cells play essential roles in immunity to viruses and tumors. Their function is genetically determined but also modulated by environmental factors. The distribution and functional regulation of these cells vary depending on the tissue. NK cell behavior in lymphoid tissues is so far understudied. Non-human primate (NHP) models are essential for the development of therapies and vaccines against human diseases, and access to NHP tissues allows insights into spatial regulations of NK cells. Here, we investigated tissue-specific parameters of NK cells from NHP species, i.e., cynomolgus macaque (Macaca fascicularis), African green monkey (Chlorocebus sabaeus), rhesus macaque (Macaca mulatta), and baboon (Papio anubis). By comprehensive multi-dimensional analysis of NK cells from secondary lymphoid organs, intestinal mucosa, liver, and blood, we identified tissue- and species-specific patterns of NK cell frequencies, phenotypes, and potential activity. Also, we defined the tissue-specific characteristics of NK cells during infection by the simian immunodeficiency virus. Altogether, our results provide a comprehensive anatomic analysis of NK cells in different tissues of primates at steady-state and during a viral infection.
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影响因子：
7.3
作者：
Gaynor LM;Colucci F
通讯作者：
Colucci F
影响因子：
8.7
作者：
Estes JD
通讯作者：
Estes JD
影响因子：
17.1
作者：
Horowitz A;Strauss-Albee DM;Leipold M;Kubo J;Nemat-Gorgani N;Dogan OC;Dekker CL;Mackey S;Maecker H;Swan GE;Davis MM;Norman PJ;Guethlein LA;Desai M;Parham P;Blish CA
通讯作者：
Blish CA
影响因子：
4.4
作者：
Chuang, SS;Kumaresan, PR;Mathew, PA
通讯作者：
Mathew, PA
影响因子：
20.3
作者：
Beuneu, Helene;Deguine, Jacques;Bousso, Philippe
通讯作者：
Bousso, Philippe