Ftz-F1H promotes white spot syndrome virus infection in shrimp by suppressing the Dorsal pathway
Ftz-F1H promotes white spot syndrome virus infection in shrimp by suppressing the Dorsal pathway
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Ftz-F1H 通过抑制背侧途径促进虾白斑综合症病毒感染
DOI：
10.1016/j.aquaculture.2021.737708
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发表时间：
2021-11
期刊：
影响因子：
4.5
通讯作者：
Xu Xiaopeng
中科院分区：
文献类型：
--
作者：
Weng Kejia;Zuo Hongliang;Zhu Zhiming;Guo Zhixun;Weng Shaoping;He Jianguo;Xu Xiaopeng
白色斑点综合征病毒（White Spot Syndrome Virus，WSSV）是目前养殖对虾的主要病毒病原。NF-κ B信号转导在无脊椎动物和脊椎动物的免疫应答调节中起着重要作用。Dorsal是节肢动物NF-κ B家族成员，在对虾抗病毒反应中起重要作用。Ftz-F1 H是一种新发现的太平洋白色对虾孤儿核受体，具有抗副溶血性弧菌（Vibrio parahaemolyticus）的作用。本研究探讨了Ftz-F1H在抗WSSV感染的免疫应答中的作用。我们发现Ftz-F1H直接促进对虾Dorsal途径的胞质抑制剂Cactus的表达，并抑制Dorsal的核转位。体内沉默Ftz-F1H1基因可抑制对虾WSSV感染。提示Ftz-F1H可能通过抑制Dorsal途径的激活而促进WSSV的感染。这项研究，加上以前的发现，表明Ftz-F1H抑制虾可以提高对细菌和病毒感染的防御。
White spot syndrome virus (WSSV) is currently a major viral pathogen of cultured shrimp. The NF-κB signaling is central to the regulation of immune responses in both invertebrates and vertebrates. Dorsal is a member of the NF-κB family in arthropods, playing important role in shrimp antiviral response. Thefushi tarazu(FTZ) transcription factor (Ftz-F1) homologue (Ftz-F1H) is a novel identified orphan nuclear receptor in Pacific white shrimp Penaeusvannameiwith an inhibitory effect on anti-Vibrio parahaemolyticus response. The current study investigated the role of Ftz-F1H in the immune response against WSSV infection. We showed that Ftz-F1H directly promoted the expression of Cactus, the cytoplasmic inhibitor of the Dorsal pathway in shrimp, and inhibited the nuclear translocation of Dorsal. Silencing of Ftz-F1Hin vivosuppressed the WSSV infection in shrimp. These suggested that Ftz-F1H could promote WSSV infection by inhibiting the activation of the Dorsal pathway. This study, together with the previous finding, indicated that inhibition of Ftz-F1H in shrimp could enhance the defense against both bacterial and viral infections.
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